Combined Therapy with Laser and Autologous Topical Serum for Facial Rejuvenation: A Multiple Case Series Report

Abstract

Background: Lasers require several sessions to achieve significant results and may lead to adverse reactions. Platelet-rich plasma (PRP) therapy is a good adjuvant to laser therapies; however, repeated blood extractions and invasive injections are needed. A 100% autologous topical formulation based on the patient's proteins has been recently developed, known as Endoret-Serum (ES). Unlike other PRPs, ES provides a home care, storable, and topical needle-free application.

Objective: Preliminarily assess the clinical performance of a single session of the combined therapy with nonablative laser and ES in the management of cutaneous pigmented and vasculature lesions.

Materials and methods: Nine patients with clinical signs of skin aging received a single session of nonablative laser. ES was topically applied twice daily. They were clinically assessed after 1 and 8 weeks. VISIA-CR System was used for high-resolution topographic analysis. Subjects were asked to complete a self-assessment questionnaire and an impression of improvement survey. An investigator's global assessment scale was fulfilled.

Results: The combined treatment improved cutaneous spots, wrinkles, and texture after 8 weeks, whereas significant pore reduction was observable at 1 week. Ultraviolet (UV) spots and porphyrins decreased at 1 week, whereas red area improvement was noticeable after 8 weeks. Overall wrinkle amelioration, periorbital hyperpigmentation decrease, softened skin, and tone recovery was observed. Patients referred to be very satisfied and felt that their cutaneous condition was much better. At the end of the study, subjects presented minimal dermatological symptoms like pigmented lesions, redness, or capillaries. No side effects were reported.

Conclusion: Results presented herein suggest that one session of laser in combination with ES provides a good clinical outcome.

Keywords: Autologous topical serum; laser; platelet-rich plasma; skin rejuvenation.

Figure 1

Skin complexion analysis using the VISIA-CR System. (A and B) Combined treatment showed to improve spot percentile after 8 weeks. (C and D) Wrinkle reduction was noticeable at 8 weeks. (E and F) Texture improvement achieved the statistical significance after 8 weeks. (G and H) Pore index decreased 1 week after treatment. *Statistically significant differences compared to baseline (*P ≤ 0.05)

Figure 2

Skin complexion analysis using the VISIA-CR System. (A and B) Combined treatment showed to improve UV spot percentile after 1 week. (C and D) Although brown spots showed a slight improvement after 1 week, the statistical significance was not reached. (E and F) Red area improvement achieved the statistical significance after 8 weeks. (G and H) Porphyrin index decreased 1 week after treatment. *Statistically significant differences compared to baseline (*P ≤ 0.05)

Figure 3

Standardized facial photographs of patients during the study at baseline, just after the laser treatment and at the end of the follow-up period