Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;65(12):1557-1572.
doi: 10.1111/dmcn.15588. Epub 2023 Apr 10.

Early brain magnetic resonance imaging findings and neurodevelopmental outcome in children with congenital heart disease: A systematic review

Emma I Dijkhuizen  1 , Sophie de Munck  2 , Rogier C J de Jonge  1 , Karolijn Dulfer  1 , Ingrid M van Beynum  2   3 , Maayke Hunfeld  1   4 , André B Rietman  2   5 , Koen F M Joosten  1 , Neeltje E M van Haren  5
Affiliations
Free article

Early brain magnetic resonance imaging findings and neurodevelopmental outcome in children with congenital heart disease: A systematic review

Emma I Dijkhuizen et al. Dev Med Child Neurol. 2023 Dec.
Free article

Abstract

Aim: To investigate the association between early brain magnetic resonance imaging (MRI) findings and neurodevelopmental outcome (NDO) in children with congenital heart disease (CHD).

Method: A search for studies was conducted in Embase, Medline, Web of Science, Cochrane Central, PsycINFO, and Google Scholar. Observational and interventional studies were included, in which patients with CHD underwent surgery before 2 months of age, a brain MRI scan in the first year of life, and neurodevelopmental assessment beyond the age of 1 year.

Results: Eighteen studies were included. Thirteen found an association between either quantitative or qualitative brain metrics and NDO: 5 out of 7 studies showed decreased brain volume was significantly associated with worse NDO, as did 7 out of 10 studies on brain injury. Scanning protocols and neurodevelopmental tests varied strongly.

Interpretation: Reduced brain volume and brain injury in patients with CHD can be associated with impaired NDO, yet standardized scanning protocols and neurodevelopmental assessment are needed to further unravel trajectories of impaired brain development and its effects on outcome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Euro-Peristat Project. European Perinatal Health Report. Core indicators of the health and care of pregnant women and babies in Europe in 2015. November 2018; Available at www.europeristat.com.
    1. Broeders L, Achterberg PW, Waelput AJM, Ravelli ACJ, Kwee A, Groenendaal F, et al. Decrease in foetal and neonatal mortality in the Netherlands; comparison with other Euro-Peristat countries in 2004, 2010 and 2015 Afname van foetale en neonatale sterfte in Nederland. Ned Tijdschr Geneeskd. 2019;163.
    1. Howell HB, Zaccario M, Kazmi SH, Desai P, Sklamberg FE, Mally P. Neurodevelopmental outcomes of children with congenital heart disease: A review. Curr Probl Pediatr Adolesc Health Care. 2019;49(10):100685.
    1. Marino BS, Lipkin PH, Newburger JW, Peacock G, Gerdes M, Gaynor JW, et al. Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association. Circulation. 2012;126(9):1143-72.
    1. Latal B. Neurodevelopmental Outcomes of the Child with Congenital Heart Disease. Clin Perinatol. 2016;43(1):173-85.

Publication types

MeSH terms

LinkOut - more resources