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Review
. 2023 Jun;41(4):392-398.
doi: 10.1002/cbf.3792. Epub 2023 Apr 10.

SGLT2 inhibitors and autophagy in diabetes

Habib Yaribeygi  1 , Mina Maleki  2 , Stephen L Atkin  3 , Tannaz Jamialahmadi  4   5 , Amirhossein Sahebkar  5   6   7
Affiliations
Review

SGLT2 inhibitors and autophagy in diabetes

Habib Yaribeygi et al. Cell Biochem Funct. 2023 Jun.

Abstract

Autophagy is a physiological event in mammalian cells to promote cell survival and efficiency in tissues, but it may turn to be a pathological process in disease conditions such as in diabetes. Chronic hyperglycemia induces aberrant autophagy and promotes cellular death as a main underlying cause of diabetes-related complications. Therefore, autophagy-modifying therapy may be of value to prevent the development of complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of newly introduced antidiabetic drugs that achieve normoglycemia through causing overt glycosuria. There is evidence that these drugs may have pleiotropic extra-glycemic benefits, but their effect on the autophagy process is unclear; therefore, this review was undertaken to clarify the possible effects of SGLT2is on autophagy.

Keywords: SGLT2i; autophagy; diabetes mellitus; sodium-glucose cotransporter 2 inhibitors; sodium-hydrogen exchangers.

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References

REFERENCES

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