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Review
. 2023 Aug;317(1):20-29.
doi: 10.1111/imr.13204. Epub 2023 Apr 10.

Emerging roles of lysophosphatidylserine as an immune modulator

Shun Yaginuma  1 , Jumpei Omi  1 , Akiharu Uwamizu  1 , Junken Aoki  1
Affiliations
Review

Emerging roles of lysophosphatidylserine as an immune modulator

Shun Yaginuma et al. Immunol Rev. 2023 Aug.

Abstract

In addition to direct activation by pathogens and antigens, immune cell functions are further modulated by factors in their environment. Recent studies have revealed that lysophospholipids (LPL) derived from membrane glycerophospholipids are such environmental factors. They are produced by the action of various phospholipases and modulate immune responses positively or negatively via G-protein-coupled receptor-type receptors. These include lysophosphatidic acid, lysophosphatidylserine (LysoPS), and lysophosphatidylinositol. Here, we summarize what is known about the synthetic pathways, receptors, and immunomodulatory functions of these LPLs. Particular focus is given to LysoPS, which have recently been identified, and recent findings on their immunomodulatory actions are presented.

Keywords: G-protein-coupled receptor; immune modulation; lysophosphatidic acid; lysophosphatidylinositol; lysophosphatidylserine; lysophospholipids.

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References

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