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Editorial
. 2023 Apr 11;147(15):1180-1182.
doi: 10.1161/CIRCULATIONAHA.123.064250. Epub 2023 Apr 10.

Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts

Junichi Sadoshima  1
Affiliations
Editorial

Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts

Junichi Sadoshima. Circulation. .
No abstract available

Keywords: Editorials; caveolin 3; heart; insulin resistance; insulins; prediabetic state.

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Figures

Figure 1.
Figure 1.
Nitration of Caveolin-3 (Cav-3) at Tyrosine 73 (Tyr73–3NT) induces insulin resistance and increases susceptibility to myocardial ischemia in prediabetic mouse hearts. ONOO− is produced near Cav-3 in the presence of O2− and NO. Tyr73–3NT in the caveolin scaffolding domain (Cav scaff domain) prevents signalosome formation and disrupts transmembrane signaling through insulin receptors (InsRs), adiponectin receptors (AdipoRs) and other receptors. ONOO− may be scavenged in the presence of superoxide dismutase (SOD), peroxiredoxin (Prx) or ebselen, a glutathione peroxidase mimetic.
See this image and copyright information in PMC

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References

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