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. 2023 May:110:105392.
doi: 10.1016/j.parkreldis.2023.105392. Epub 2023 Apr 1.

Early rapid eye movement sleep behavior disorder predicts incident cognitive impairment in Parkinson's disease across ages

Lauren E Kenney  1 , Adrianna M Ratajska  2 , Francesca V Lopez  3 , Michael Marsiske  4 , Dawn Bowers  5
Affiliations

Early rapid eye movement sleep behavior disorder predicts incident cognitive impairment in Parkinson's disease across ages

Lauren E Kenney et al. Parkinsonism Relat Disord. 2023 May.

Abstract

This study demonstrated possible rapid eye movement sleep behavior disorder (RBD)'s relationship to longitudinal, incident cognitive impairment in the Parkinson's Progression Markers Initiative (PPMI) database. Age did not moderate this relationship, suggesting that RBD serves as a cognitive risk factor across individuals of all ages with recently diagnosed Parkinson's disease.

Keywords: Cognition; Parkinson's disease; Rapid eye movement sleep behavior disorder; Risk factors; Survival analyses.

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Conflict of interest statement

Declaration of competing interest None.

Figures

Figure 1.
Figure 1.
Cumulative Survival Curves. Survival curves are presented (A) for the full sample, (B) for each group with and without RBD status at baseline, (C) for RBD status groups further split by age classification, and (d) for the fitted regression model. BL=Baseline; RBD=REM Behavior Sleep Disorder;Young=below mean age; Old=above mean age; Age −1=1 standard deviation below mean age;Age0=mean age; Age1=1 standard deviation above mean age
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