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Case Reports
. 2023 Jun:131:162-165.
doi: 10.1016/j.ijid.2023.04.007. Epub 2023 Apr 8.

Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity

Jacqueline D Squire  1 , Claudia R Libertin  2 , Harry Powers  2 , Jared Nelson  2 , Lisa Brumble  2 , Federico R Laham  3 , Anahita Agharahimi  4 , Alexandra F Freeman  4 , Jennifer W Leiding  5
Affiliations
Case Reports

Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity

Jacqueline D Squire et al. Int J Infect Dis. 2023 Jun.

Abstract

Tumor necrosis factor-a inhibitors can be associated with increased risk of infections, particularly reactivation of latent tuberculosis or nontuberculous mycobacterium (NTM). However, because disseminated NTM is rare, inborn errors of immunity should be considered. We present three patients with disseminated NTM after tumor necrosis factor-a inhibitor use who were found to have inborn errors of immunity.

Keywords: Immunodeficiency; Inborn errors of immunity; Infliximab; Mycobacteria; TNF inhibitor.

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Conflict of interest statement

Declaration of competing interest The authors have no competing interests to declare.

Figures

Figure 1.
Figure 1.
Clinical Images of Mycobacterium Avium Complex Infections from Cases A) Patient 1 skin lesions, initial biopsy showed lobular panniculitis with suppurative necrosis. B) Patient 1 large right perihilar pulmonary opacity with worsening mediastinal adenopathy C) Patient 2 PET scan demonstrating hypermetabolic right cervical neck and extensive abdominopelvic lymphadenopathy, right parietal scalp lesion, and hypermetabolic activity in lytic L1 lesion
See this image and copyright information in PMC

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