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. 2023 Apr 10;41(4):637-640.
doi: 10.1016/j.ccell.2023.03.012.

Pre-cancer: From diagnosis to intervention opportunities

E Shelley Hwang, James Reading, Jun Yu, Gian Paolo Dotto, William M Grady, Bogdan Czerniak, Manuel Serrano
Free article

Pre-cancer: From diagnosis to intervention opportunities

E Shelley Hwang et al. Cancer Cell. .
Free article

Abstract

The multi-step process of carcinogenesis implies the existence of pre-malignant yet altered states that involve both the potentially carcinogenic cell as well as its surrounding microenvironment. Experts discuss some tumor types for which clear pre-cancerous stages have been identified and mention key biological alterations used for diagnosis and intervention strategies.

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Conflict of interest statement

Declaration of interests G.P.D. has filed the following patents: Methods and compositions for preventing skin damage, patent # US 7,192,770; In vivo screening array, patent # US 7,202,392; Methods and compositions for Reducing skin damage (Notch), patent # 8,114,422; and Methods and compositions for the treatment of cancer, patent # US10188747B2, WO2015130477A1. W.M.G. is a scientific advisory board member for Freenome, Natera, Guardant Health, and SEngine and consultant for DiaCarta, Nephron, Guidepoint, and GLG. W.M.G. is an investigator in a clinical trial sponsored by Janssen Pharmaceuticals and receives research support from Tempus and LucidDx.

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