Adoptive cell transfer immunotherapy for patients with solid epithelial cancers
- PMID: 37037613
- PMCID: PMC10184665
- DOI: 10.1016/j.ccell.2023.03.003
Adoptive cell transfer immunotherapy for patients with solid epithelial cancers
Abstract
Efforts to apply adoptive cell transfer (ACT) immunotherapy to patients with common epithelial cancers have been stimulated by the demonstration that the majority of these patients contain lymphocytes reactive against the expressed products of their cancer mutations. Early efforts to specifically target these antigens have been promising.
Copyright © 2023. Published by Elsevier Inc.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
References
-
- Rosenberg SA, Packard BS, Aebersold PM, Solomon D, Topalian SL, Toy ST, Simon P, Lotze MT, Yang JC, Seipp CA, et al. (1988). Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N. Engl. J. Med. 319, 1676–1680. 10.1056/NEJM198812223192527. - DOI - PubMed
-
- Seitter SJ, Sherry RM, Yang JC, Robbins PF, Shindorf ML, Copeland AR, McGowan CT, Epstein M, Shelton TE, Langhan MM, et al. (2021). Impact of prior treatment on the Efficacy of adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma. Clin. Cancer Res. 27, 5289–5298. 10.1158/1078-0432.CCR-21-1171. - DOI - PMC - PubMed
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