Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr 11;39(6):155.
doi: 10.1007/s11274-023-03610-7.

Biological activities and applications of exopolysaccharides produced by lactic acid bacteria: a mini-review

Yi Yang  1   2 , Guangyang Jiang  1   2 , Yongqiang Tian  3   4
Affiliations
Review

Biological activities and applications of exopolysaccharides produced by lactic acid bacteria: a mini-review

Yi Yang et al. World J Microbiol Biotechnol. .

Abstract

Exopolysaccharides (EPSs) are naturally occurring high-molecular-weight carbohydrates that have been widely studied for their biological activities, including antioxidant, immunomodulatory, anticancer and gut microbiota regulation activities. Polysaccharides are abundant in nature and can be derived from animals, plants, algae, and microorganisms, but among polysaccharides with potential uses, EPSs from microorganisms have the advantages of a short production cycle, high yield, and independence of production from season and climate and thus have broad prospects. While the safety of the producing microorganism can represent a problem in application of microbial EPSs, lactic acid bacteria (LAB) have been used by humans for thousands of years, and they and their products are generally recognized as safe. This makes LAB excellent sources for exopolysaccharides. EPS-producing LAB are readily found in nature. Through screening of strains, optimization of culture conditions, and improvement of the growth medium, the yield of EPSs from LAB can be increased and the scope of application broadened. This review summarizes EPSs from LAB in terms of structure, function and applications, as well as yield optimization, and introduces recent research on the biological activities and practical applications of LAB EPSs, aiming to provide references for researchers in related areas.

Keywords: Anticancer; Antioxidant; Exopolysaccharide; Immunomodulatory; Lactic acid bacteria; Probiotic.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Acosta Aragon Y, Jatkauskas J, Vrotniakiene V (2012) The effect of a silage inoculant on silage quality, aerobic stability, and meat production on farm scale. ISRN Veterinary Science 2012:345927–345927. https://doi.org/10.5402/2012/345927 - DOI - PubMed - PMC
    1. Ai LZ, Zhang H, Guo BH et al (2008) Preparation, partial characterization and bioactivity of exopolysaccharides from Lactobacillus casei LC2W. Carbohyd Polym 74(3):353–357. https://doi.org/10.1016/j.carbpol.2008.03.004 - DOI
    1. Altmann F, Kosma P, O’Callaghan A et al (2016) Genome analysis and characterisation of the exopolysaccharide produced by Bifidobacterium longum subsp. longum 35624 (TM). PLoS ONE 11(9). https://doi.org/10.1371/journal.pone.0162983
    1. Amrouche T, Boutin Y, Prioult G, Fliss I (2006) Effects of bifidobacterial cytoplasm, cell wall and exopolysaccharide on mouse lymphocyte proliferation and cytokine production. Int Dairy J 16(1):70–80. https://doi.org/10.1016/j.idairyj.2005.01.008 - DOI
    1. Angelin J, Kavitha M (2020) Exopolysaccharides from probiotic bacteria and their health potential. Int J Biol Macromol 162:853–865. https://doi.org/10.1016/j.ijbiomac.2020.06.190 - DOI - PubMed - PMC

LinkOut - more resources