Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2024 May;29(3):564-572.
doi: 10.1111/nicc.12915. Epub 2023 Apr 11.

Venous thromboembolism prophylaxis and mortality in patients with spinal fractures in ICUs

Shaojin Li  1 , Luming Zhang  2   3 , Haiyan Yin  2 , Guowei Zhang  1 , Minghui Tan  1 , Zhenbin Cai  1 , Tao Huang  3 , Hongsheng Lin  1 , Jun Lyu  3
Affiliations
Multicenter Study

Venous thromboembolism prophylaxis and mortality in patients with spinal fractures in ICUs

Shaojin Li et al. Nurs Crit Care. 2024 May.

Abstract

Background: Spinal fracture is a common traumatic condition in orthopaedics, accounting for 5%-6% of total body fractures, and is a high-risk factor for venous thromboembolism (VTE), which seriously affects patient prognosis.

Aim: The aim of this study was to determine the impact of VTE prophylaxis on the prognosis of patients with spinal fractures in intensive care units (ICUs) and to provide a scientific basis for clinical treatment and nursing.

Design: A retrospective study of patients with spinal fractures from the multicenter eICU Collaborative Research Database.

Method: The outcomes of this study were ICU mortality and in-hospital mortality. Patients were divided into the VTE prophylaxis (VP) and no VTE prophylaxis (NVP) groups according to whether they had undergone VTE prophylaxis during their ICU admission. The association between groups and outcomes were analysed using Kaplan-Meier (KM) survival curve, log-rank test and the Cox proportional-hazards regression model.

Results: This study included 1146 patients with spinal fractures: 330 in the VP group and 816 in the NVP group. KM survival curves and log-rank tests revealed that both ICU and in-hospital survival probabilities in the VP group were significantly higher than in the NVP group. After the Cox model was adjusted for all covariates, the hazard ratio for ICU mortality in the VP group was 0.38 (0.19-0.75); the corresponding value for in-hospital mortality in the VP group was 0.38 (0.21-0.68).

Conclusions: VTE prophylaxis is associated with reduced ICU and in-hospital mortality in patients with spinal fractures in ICUs. More research is necessary to further define specific strategies and optimal timing for VTE prophylaxis.

Relevance to clinical practice: This study provides the basis that VTE prophylaxis may be associated with improved prognosis in patients with spinal fractures in ICUs. In clinical practice, an appropriate modality should be selected for VTE prophylaxis in such patients.

Keywords: ICUs; mortality; prophylaxis; spinal fracture; venous thromboembolism.

PubMed Disclaimer

Similar articles

See all similar articles

References

REFERENCES

    1. Bouyer B, Vassal M, Zairi F, et al. Surgery in vertebral fracture: epidemiology and functional and radiological results in a prospective series of 518 patients at 1 year's follow‐up. Orthop Traumatol Surg Res. 2015;101(1):11‐15.
    1. Baaj AA, Downes K, Vaccaro AR, Uribe JS, Vale FL. Trends in the treatment of lumbar spine fractures in the United States: a socioeconomics perspective: clinical article. J Neurosurg Spine. 2011;15(4):367‐370.
    1. Oliver M, Inaba K, Tang A, et al. The changing epidemiology of spinal trauma: a 13‐year review from a Level I trauma centre. Injury. 2012;43(8):1296‐1300.
    1. Zhang W, Huai Y, Wang W, et al. A retrospective cohort study on the risk factors of deep vein thrombosis (DVT) for patients with traumatic fracture at Honghui Hospital. BMJ Open. 2019;9(3):e024247.
    1. Zhao Z, Tian Q, Zhang B. Effects of rehabilitation nursing care on deep vein thrombosis of the lower limbs following spinal fractures. Am J Transl Res. 2021;13(3):1877‐1883.

Publication types

LinkOut - more resources