[Neuroimmunology of allergic rhinitis : Part 1: Cellular and humoral basic principles]

doi:10.1007/s00106-023-01292-z

Review

. 2023 May;71(5):337-346.

doi: 10.1007/s00106-023-01292-z. Epub 2023 Apr 11.

[Neuroimmunology of allergic rhinitis : Part 1: Cellular and humoral basic principles]

[Article in German]

L Klimek¹, P Werminghaus², C Bergmann³, J Hagemann⁴, T Huppertz⁴, F Bärhold⁵, F Klimek⁶, K Dziadziulia⁶, I Casper⁶, M-L Polk⁷, M Cuevas⁷, M Gröger⁸, S Becker⁵

Affiliations

¹ Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland. Ludger.Klimek@Allergiezentrum.org.
² Praxis für Hals‑, Nasen‑, Ohrenheilkunde und Allergologie, Düsseldorf, Deutschland.
³ Praxis für Hals‑, Nasen‑, Ohrenheilkunde, Klinik RKM 740, Düsseldorf, Deutschland.
⁴ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsmedizin Mainz, Mainz, Deutschland.
⁵ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinik Tübingen, Tübingen, Deutschland.
⁶ Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
⁷ Klinik und Poliklinik für HNO-Heilkunde, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Deutschland.
⁸ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinik München, München, Deutschland.

PMID: 37041304
DOI: 10.1007/s00106-023-01292-z

Review

[Neuroimmunology of allergic rhinitis : Part 1: Cellular and humoral basic principles]

[Article in German]

L Klimek et al. HNO. 2023 May.

. 2023 May;71(5):337-346.

doi: 10.1007/s00106-023-01292-z. Epub 2023 Apr 11.

Authors

L Klimek¹, P Werminghaus², C Bergmann³, J Hagemann⁴, T Huppertz⁴, F Bärhold⁵, F Klimek⁶, K Dziadziulia⁶, I Casper⁶, M-L Polk⁷, M Cuevas⁷, M Gröger⁸, S Becker⁵

Affiliations

¹ Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland. Ludger.Klimek@Allergiezentrum.org.
² Praxis für Hals‑, Nasen‑, Ohrenheilkunde und Allergologie, Düsseldorf, Deutschland.
³ Praxis für Hals‑, Nasen‑, Ohrenheilkunde, Klinik RKM 740, Düsseldorf, Deutschland.
⁴ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsmedizin Mainz, Mainz, Deutschland.
⁵ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinik Tübingen, Tübingen, Deutschland.
⁶ Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
⁷ Klinik und Poliklinik für HNO-Heilkunde, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Deutschland.
⁸ Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinik München, München, Deutschland.

PMID: 37041304
DOI: 10.1007/s00106-023-01292-z

Abstract
in English, German

Allergic rhinitis (AR) is a very common disease with a high prevalence worldwide. It is an IgE-mediated type 2 inflammatory disease following exposure to inhalant allergens. A multitude of different neuropeptides including substance P, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), nerve growth factor (NGF), and neuromedin U (NMU) can be released via peripheral axon or central reflexes, interact with immune cells, and thus contribute to neurogenic inflammation which causes the nasal hyperreactivity (NHR) characteristic of AR. Independent production of neuroendocrine hormones and neuropeptides by immune cells has also been demonstrated. Neuro-immune cell units arise when immune and neuronal cells colocalize, for which typical anatomic regions are, e.g., the mast cell-nerve functional unit. The focus of this review is the elucidation of neuroimmune communication mechanisms in AR.

Die allergische Rhinitis (AR) ist eine sehr häufige Erkrankung mit weltweit hoher Prävalenz. Sie ist eine IgE-vermittelte und entzündungsbedingte Typ-2-Erkrankung nach Exposition gegenüber inhalativen Allergenen. Eine Vielzahl von Neuropeptiden wie Substanz P (SP), vasoaktives intestinales Peptid (VIP), „calcitonin gene-related peptide“ (CGRP), Nervenwachstumsfaktor (NGF) und Neuromedin U (NMU) können über periphere Axonreflexe oder zentrale Reflexe freigesetzt werden, mit Immunzellen interagieren und sind so an einer neurogenen Entzündung beteiligt, die zur nasalen Hyperreaktivität (NHR) der AR führt. Die eigenständige Produktion von neuroendokrinen Hormonen und Neuropeptiden durch Immunzellen wurde ebenfalls nachgewiesen. Neuroimmunzellverbände entstehen, wenn Immun- und neuronale Zellen kolokalisieren. Typische anatomische Regionen dafür sind beispielsweise die Nerv-Mastzellen-Einheit. In dieser Übersicht liegt der Fokus auf der Ausarbeitung neuroimmunologischer Kommunikationsmechanismen der AR.

Keywords: Allergy and immunology; Intracellular signaling peptides and proteins; Ion channels; Neurotransmitter; Rhinorrhea.

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References

Literatur

1. Gelincik A, Aydın F, Ozerman B et al (2012) Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis. Ann Allergy Asthma Immunol 108:396–401. https://doi.org/10.1016/j.anai.2012.04.006 - DOI - PubMed
1. Klimek L, Bachert C, Pfaar O et al (2019) ARIA guideline 2019: treatment of allergic rhinitis in the German health system. Allergol Sel 3:22–50. https://doi.org/10.5414/ALX02120E - DOI
1. Klimek L, Brehler R, Hamelmann E et al (2019) Evolution of subcutaneous allergen immunotherapy (part 1): from first developments to mechanism-driven therapy concepts. Allergo J Int 28:78–95 - DOI
1. Klimek L, Brehler R, Hamelmann E et al (2019) Development of subcutaneous allergen immunotherapy (part 2): preventive aspects and innovations. Allergo J Int 28:107–119 - DOI
1. Sanico AM, Stanisz AM, Gleeson TD et al (2000) Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med 161:1631–1635. https://doi.org/10.1164/ajrccm.161.5.9908028 - DOI - PubMed

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[1] Gelincik A, Aydın F, Ozerman B et al (2012) Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis. Ann Allergy Asthma Immunol 108:396–401. https://doi.org/10.1016/j.anai.2012.04.006 - DOI - PubMed

[2] Gelincik A, Aydın F, Ozerman B et al (2012) Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis. Ann Allergy Asthma Immunol 108:396–401. https://doi.org/10.1016/j.anai.2012.04.006 - DOI - PubMed

[3] Klimek L, Bachert C, Pfaar O et al (2019) ARIA guideline 2019: treatment of allergic rhinitis in the German health system. Allergol Sel 3:22–50. https://doi.org/10.5414/ALX02120E - DOI

[4] Klimek L, Bachert C, Pfaar O et al (2019) ARIA guideline 2019: treatment of allergic rhinitis in the German health system. Allergol Sel 3:22–50. https://doi.org/10.5414/ALX02120E - DOI

[5] Klimek L, Brehler R, Hamelmann E et al (2019) Evolution of subcutaneous allergen immunotherapy (part 1): from first developments to mechanism-driven therapy concepts. Allergo J Int 28:78–95 - DOI

[6] Klimek L, Brehler R, Hamelmann E et al (2019) Evolution of subcutaneous allergen immunotherapy (part 1): from first developments to mechanism-driven therapy concepts. Allergo J Int 28:78–95 - DOI

[7] Klimek L, Brehler R, Hamelmann E et al (2019) Development of subcutaneous allergen immunotherapy (part 2): preventive aspects and innovations. Allergo J Int 28:107–119 - DOI

[8] Klimek L, Brehler R, Hamelmann E et al (2019) Development of subcutaneous allergen immunotherapy (part 2): preventive aspects and innovations. Allergo J Int 28:107–119 - DOI

[9] Sanico AM, Stanisz AM, Gleeson TD et al (2000) Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med 161:1631–1635. https://doi.org/10.1164/ajrccm.161.5.9908028 - DOI - PubMed

[10] Sanico AM, Stanisz AM, Gleeson TD et al (2000) Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med 161:1631–1635. https://doi.org/10.1164/ajrccm.161.5.9908028 - DOI - PubMed

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[Neuroimmunology of allergic rhinitis : Part 1: Cellular and humoral basic principles]

Affiliations

[Neuroimmunology of allergic rhinitis : Part 1: Cellular and humoral basic principles]

Authors

Affiliations

Abstract
in English, German

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Cited by

References

Literatur

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Full Text Sources

Research Materials

Abstract in English, German

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Literatur

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Abstract
in English, German