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. 2023 Jun;33(6):1876-1888.
doi: 10.1007/s11695-023-06567-6. Epub 2023 Apr 11.

Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review)

Sotirios G Doukas  1 , Panagiotis G Doukas  2 , Dimitra P Vageli  2 , Arkady Broder  3
Affiliations

Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review)

Sotirios G Doukas et al. Obes Surg. 2023 Jun.

Abstract

Bariatric bypass surgery has been an effective treatment for morbid obesity. However, there is an increasing number of reported cases of gastric cancer after bypass surgery. Our systematic review showed an increasing trend of gastric cancer cases after bariatric bypass surgery in the last decade, mostly located in the excluded stomach (77%) and diagnosed in an advanced stage. In addition to known risk factors such as tobacco smoking (17%), H. pylori infection (6%), and family history of gastric cancer (3%), bile reflux, a recently proposed cancer-promoting factor, was also estimated in 18% of the cases. Our data suggest that gastric cancer risk assessment should be considered before gastric bypass surgery, and further investigations are needed to determine the value of post-operative gastric cancer surveillance.

Keywords: Bariatric surgery; Bile reflux; Gastric bypass; Gastric cancer; Roux-en-Y; Stomach cancer.

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