Biological BMI uncovers hidden health risks and is more responsive to lifestyle shifts

No authors listed

Comment

No authors listed. Nat Med. 2023 Apr.

. 2023 Apr;29(4):801-802.

doi: 10.1038/s41591-023-02283-x.

No abstract available

Comment on

Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.
Watanabe K, Wilmanski T, Diener C, Earls JC, Zimmer A, Lincoln B, Hadlock JJ, Lovejoy JC, Gibbons SM, Magis AT, Hood L, Price ND, Rappaport N. Watanabe K, et al. Nat Med. 2023 Apr;29(4):996-1008. doi: 10.1038/s41591-023-02248-0. Epub 2023 Mar 20. Nat Med. 2023. PMID: 36941332 Free PMC article.

1. Haslam, D. W. & James, W. P. T. Obesity. Lancet 366, 1197–209 (2005). A widely read review article that gives a comprehensive overview of obesity from a medical perspective. - DOI - PubMed
1. Smith, G. I., Mittendorfer, B. & Klein, S. Metabolically healthy obesity: facts and fantasies. J. Clin. Invest. 129, 3978–3989 (2019). A review article that outlines the characteristics and outcomes of individuals with metabolically healthy obesity. - DOI - PubMed - PMC
1. Stefan, N., Schick, F. & Häring, H.-U. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metab. 26, 292–300 (2017). A review article that outlines the causes, characteristics and clinical implications for individuals who are metabolically unhealthy with a normal weight. - DOI - PubMed
1. Karczewski, K. J. & Snyder, M. P. Integrative omics for health and disease. Nat. Rev. Genet. 19, 299–310 (2018). A review article that outlines recent advancements in -omics measurement technology and the use of integrative -omics. - DOI - PubMed - PMC
1. Earls, J. C. et al. Multi-omic biological age estimation and its correlation with wellness and disease phenotypes: a longitudinal study of 3,558 individuals. J. Gerontol. A. Biol. Sci. Med. Sci. 74, S52–S60 (2019). A paper that developed a multi-omics-based measure of biological age. - DOI - PubMed - PMC