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Review
. 2022 Dec 24:13:e75.
doi: 10.34172/jlms.2022.75. eCollection 2022.

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

Mahnaz Poorhassan  1 , Morteza Gholaminejhad  2 , Houssein Ahmadi  3 , Leila Mehboudi  4 , Mahdis Chahar Kameh  5 , Maryam Pirani  3 , Gholamreza Hassanzadeh  2   6
Affiliations
Review

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

Mahnaz Poorhassan et al. J Lasers Med Sci. .

Abstract

About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca2+, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.

Keywords: Asthenozoospermia; Cryopreservation; Photobiomodulation therapy; Reactive oxygen species; Sperm motility.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

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References

    1. Moghbelinejad S, Mozdarani H, Ghoraeian P, Asadi R. Basic and clinical genetic studies on male infertility in Iran during 2000-2016: a review. Int J Reprod Biomed. 2018;16(3):131–48. - PMC - PubMed
    1. Ferlin A, Raicu F, Gatta V, Zuccarello D, Palka G, Foresta C. Male infertility: role of genetic background. Reprod Biomed Online. 2007;14(6):734–45. doi: 10.1016/s1472-6483(10)60677-3. - DOI - PubMed
    1. Chemes HE, Rawe VY. The making of abnormal spermatozoa: cellular and molecular mechanisms underlying pathological spermiogenesis. Cell Tissue Res. 2010;341(3):349–57. doi: 10.1007/s00441-010-1007-3. - DOI - PubMed
    1. Silva JV, Cruz D, Gomes M, Correia BR, Freitas MJ, Sousa L, et al. Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality. Sci Rep. 2017;7:45457. doi: 10.1038/srep45457. - DOI - PMC - PubMed
    1. Ding J, Shang X, Zhang Z, Jing H, Shao J, Fei Q, et al. FDA-approved medications that impair human spermatogenesis. Oncotarget. 2017;8(6):10714–25. doi: 10.18632/oncotarget.12956. - DOI - PMC - PubMed

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