Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

Jean Bousquet^{1

2

3}, Mohamed H Shamji^{4

5}, Josep M Anto^{6

7

8}, Holger J Schünemann⁹, G Walter Canonica^{10

11}, Marek Jutel^{12

13}, Stefano Del Giacco¹⁴, Torsten Zuberbier^{1

3}, Oliver Pfaar¹⁵, Joao A Fonseca^{16

17}, Bernardo Sousa-Pinto^{16

17}, Ludger Klimek^{18

19}, Wienczyslawa Czarlewski^{20

21}, Anna Bedbrook^{21

22}, Rita Amaral^{16

17}, Ignacio J Ansotegui²³, Sinthia Bosnic-Anticevich^{24

25

26}, Fulvio Braido^{27

28}, Claudia Chaves Loureiro²⁹, Bilun Gemicioglu³⁰, Tari Haahtela³¹, Marek Kulus³², Piotr Kuna³³, Maciej Kupczyk³³, Paolo M Matricardi³⁴, Frederico S Regateiro^{35

36

37}, Boleslaw Samolinski³⁸, Mikhail Sofiev³⁹, Sanna Toppila-Salmi³¹, Arunas Valiulis⁴⁰, Maria Teresa Ventura^{41

42}, Cristina Barbara⁴³, Karl C Bergmann^{1

3}, Michael Bewick⁴⁴, Hubert Blain⁴⁵, Matteo Bonini^{4

46

47}, Louis-Philippe Boulet⁴⁸, Rodolphe Bourret⁴⁹, Guy Brusselle⁵⁰, Luisa Brussino^{51

52}, Roland Buhl⁵³, Victoria Cardona^{54

55}, Thomas Casale⁵⁶, Lorenzo Cecchi⁵⁷, Denis Charpin⁵⁸, Ivan Cherrez-Ojeda^{59

60}, Derek K Chu⁹, Cemal Cingi⁶¹, Elisio M Costa⁶², Alvaro A Cruz⁶³, Philippe Devillier⁶⁴, Stephanie Dramburg⁶⁵, Wytske J Fokkens⁶⁶, Maia Gotua⁶⁷, Enrico Heffler^{10

11}, Zhanat Ispayeva⁶⁸, Juan Carlos Ivancevich⁶⁹, Guy Joos⁵⁰, Igor Kaidashev⁷⁰, Helga Kraxner⁷¹, Violeta Kvedariene^{72

73}, Désirée E Larenas-Linnemann⁷⁴, Daniel Laune⁷⁵, Olga Lourenço⁷⁶, Renaud Louis^{77

78}, Mika Makela³¹, Michael Makris⁷⁹, Marcus Maurer^{1

3}, Erik Melén^{80

81}, Yann Micheli⁷⁵, Mario Morais-Almeida⁸², Joaquim Mullol^{83

84}, Marek Niedoszytko⁸⁵, Robyn O'Hehir⁸⁶, Yoshitaka Okamoto^{87

88}, Heidi Olze^{89

90}, Nikolaos G Papadopoulos⁹¹, Alberto Papi⁹², Vincenzo Patella^{93

94

95}, Benoit Pétré⁹⁶, Nhân Pham-Thi^{97

98

99}, Francesca Puggioni¹⁰⁰, Santiago Quirce¹⁰¹, Nicolas Roche¹⁰², Philip W Rouadi^{103

104}, Ana Sá-Sousa^{16

17}, Hironori Sagara¹⁰⁵, Joaquin Sastre¹⁰⁶, Nicola Scichilone¹⁰⁷, Aziz Sheikh¹⁰⁸, Milan Sova¹⁰⁹, Charlotte Suppli Ulrik^{110

111}, Luis Taborda-Barata^{112

113}, Ana Todo-Bom¹¹⁴, Maria J Torres¹¹⁵, Ioanna Tsiligianni^{116

117}, Omar S Usmani^{4

118}, Erkka Valovirta¹¹⁹, Tuula Vasankari^{120

121}, Rafael José Vieira^{16

17}, Dana Wallace¹²², Susan Waserman¹²³, Mihaela Zidarn^{124

125}, Arzu Yorgancioglu¹²⁶, Luo Zhang¹²⁷, Tomas Chivato¹²⁸, Markus Ollert^{129

130}

Affiliations

¹ Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
² University Hospital Montpellier, Montpellier, France.
³ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
⁴ National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
⁵ NIHR Imperial Biomedical Research Centre, London, UK.
⁶ ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
⁷ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
⁹ Department of Health Research Methods, Evidence, and Impact, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
¹⁰ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹¹ Personalized Medicine, Asthma & Allergy, IRCCS Humanitas Research Center, Milan, Italy.
¹² Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
¹³ ALL-MED Medical Research Institute, Wroclaw, Poland.
¹⁴ Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula," University of Cagliari, Cagliari, Italy.
¹⁵ Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
¹⁶ MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁷ CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁸ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
¹⁹ Center for Rhinology and Allergology, Wiesbaden, Germany.
²⁰ Medical Consulting Czarlewski, Levallois, France.
²¹ MASK-air, Montpellier, France.
²² ARIA, Montpellier, France.
²³ Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
²⁴ Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
²⁵ Sydney Local Health District, Sydney, New South Wales, Australia.
²⁶ Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales, Australia.
²⁷ Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy.
²⁸ IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
²⁹ Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
³⁰ Department of Pulmonary Diseases, Istanbul University - Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
³¹ Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
³² Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland.
³³ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
³⁴ Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
³⁵ Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
³⁶ Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (ICBR), University of Coimbra, Coimbra, Portugal.
³⁷ Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
³⁸ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
³⁹ Finnish Meteorological Institute (FMI), Helsinki, Finland.
⁴⁰ Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁴¹ Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
⁴² Institute of Sciences of Food Production, National Research Council (Ispa-CNR), Bari, Italy.
⁴³ Portuguese National Programme for Respiratory Diseases, Direção -Geral da Saúde, Faculdade de Medicina de Lisboa, Instituto de Saúde Ambiental, Lisbon, Portugal.
⁴⁴ University of Central Lancashire Medical School, Preston, UK.
⁴⁵ Department of Geriatrics, Montpellier University Hospital, MUSE, Montpellier, France.
⁴⁶ Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy.
⁴⁷ Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli - IRCCS, Rome, Italy.
⁴⁸ Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
⁴⁹ University Hospital of Nice, Nice, France.
⁵⁰ Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
⁵¹ Department of Medical Sciences, University of Torino, Torino, Italy.
⁵² Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.
⁵³ Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany.
⁵⁴ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain.
⁵⁵ ARADyAL Research Network, Barcelona, Spain.
⁵⁶ Division of Allergy/Immunology, University of South Florida, Tampa, Florida, USA.
⁵⁷ SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
⁵⁸ Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France.
⁵⁹ Universidad Espíritu Santo, Samborondón, Ecuador.
⁶⁰ Respiralab Research Group, Guayas, Ecuador.
⁶¹ ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
⁶² UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto (Porto4Ageing), Porto, Portugal.
⁶³ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
⁶⁴ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
⁶⁵ Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany.
⁶⁶ Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
⁶⁷ Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.
⁶⁸ Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
⁶⁹ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
⁷⁰ Poltava State Medical University, Poltava, Ukraine.
⁷¹ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
⁷² Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Vilnius University, Vilnius, Lithuania.
⁷³ Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
⁷⁴ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
⁷⁵ KYomed INNOV, Montpellier, France.
⁷⁶ Faculty of Health Sciences and CICS - UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
⁷⁷ Department of Pulmonary Medicine, CHU Liège, Liège, Belgium.
⁷⁸ GIGA I3 Research Group, University of Liège, Liège, Belgium.
⁷⁹ Allergy Unit "D Kalogeromitros," 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
⁸⁰ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁸¹ Sach's Children and Youth Hospital, Stockholm, Sweden.
⁸² Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
⁸³ Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain.
⁸⁴ Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
⁸⁵ Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
⁸⁶ Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
⁸⁷ Chiba Rosai Hospital, Chiba, Japan.
⁸⁸ Chiba University Hospital, Chiba, Japan.
⁸⁹ Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁹⁰ Berlin Institute of Health, Berlin, Germany.
⁹¹ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁹² Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
⁹³ Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy.
⁹⁴ Agency of Health ASL, Salerno, Italy.
⁹⁵ Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy.
⁹⁶ Department of Public Health, University of Liège, Liège, Belgium.
⁹⁷ Ecole Polytechnique de Palaiseau, Palaiseau, France.
⁹⁸ IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France.
⁹⁹ Université Paris Cité, Paris, France.
¹⁰⁰ Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
¹⁰¹ Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
¹⁰² Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, et UMR 1016, Institut Cochin, Paris, France.
¹⁰³ Department of Otolaryngology, Head and Neck Surgery, Eye and Ear, University Hospital, Beirut, Lebanon.
¹⁰⁴ Department of Otolaryngology, Head and Neck Surgery, Dar Al Shifa Hospital - Salmiya, Hawally, Kuwait.
¹⁰⁵ Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan.
¹⁰⁶ Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain.
¹⁰⁷ PROMISE Department, University of Palermo, Palermo, Italy.
¹⁰⁸ Usher Institute, The University of Edinburgh, Edinburgh, UK.
¹⁰⁹ Department of Respiratory Medicine and Tuberculosis, University Hospital Brno, Lískovec, Czech Republic.
¹¹⁰ Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark.
¹¹¹ Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹¹² Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
¹¹³ UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
¹¹⁴ Imunoalergologia, Faculty of Medicine, Centro Hospitalar Universitário de Coimbra, University of Coimbra, Coimbra, Portugal.
¹¹⁵ Allergy Unit, Málaga Regional University Hospital-IBIMA, Málaga, Spain.
¹¹⁶ International Primary Care Respiratory Group (IPCRG), Aberdeen, UK.
¹¹⁷ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
¹¹⁸ Royal Brompton Hospital, Airways Disease Section, London, UK.
¹¹⁹ Department of Lung Diseases and Clinical Immunology, University of Turku, Turku, Finland.
¹²⁰ FIHLA, Finnish Lung Health Association, Helsinki, Finland.
¹²¹ Department of Clinical Medicine, Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
¹²² Nova Southeastern University, College of Allopathic Medicine, Fort Lauderdale, Florida, USA.
¹²³ Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
¹²⁴ University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
¹²⁵ Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
¹²⁶ Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
¹²⁷ Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital and Beijing Institute of Otolaryngology, Beijing, China.
¹²⁸ School of Medicine, University CEU San Pablo, Madrid, Spain.
¹²⁹ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
¹³⁰ Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark.

PMID: 37042071
DOI: 10.1111/all.15740

Free article

Review

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

Jean Bousquet et al. Allergy. 2023 Jul.

Free article

. 2023 Jul;78(7):1758-1776.

doi: 10.1111/all.15740.

Authors

Affiliations

¹ Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
² University Hospital Montpellier, Montpellier, France.
³ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
⁴ National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
⁵ NIHR Imperial Biomedical Research Centre, London, UK.
⁶ ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
⁷ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
⁹ Department of Health Research Methods, Evidence, and Impact, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
¹⁰ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹¹ Personalized Medicine, Asthma & Allergy, IRCCS Humanitas Research Center, Milan, Italy.
¹² Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
¹³ ALL-MED Medical Research Institute, Wroclaw, Poland.
¹⁴ Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula," University of Cagliari, Cagliari, Italy.
¹⁵ Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
¹⁶ MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁷ CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁸ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
¹⁹ Center for Rhinology and Allergology, Wiesbaden, Germany.
²⁰ Medical Consulting Czarlewski, Levallois, France.
²¹ MASK-air, Montpellier, France.
²² ARIA, Montpellier, France.
²³ Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
²⁴ Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
²⁵ Sydney Local Health District, Sydney, New South Wales, Australia.
²⁶ Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales, Australia.
²⁷ Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy.
²⁸ IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
²⁹ Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
³⁰ Department of Pulmonary Diseases, Istanbul University - Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
³¹ Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
³² Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland.
³³ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
³⁴ Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
³⁵ Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
³⁶ Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (ICBR), University of Coimbra, Coimbra, Portugal.
³⁷ Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
³⁸ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
³⁹ Finnish Meteorological Institute (FMI), Helsinki, Finland.
⁴⁰ Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁴¹ Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
⁴² Institute of Sciences of Food Production, National Research Council (Ispa-CNR), Bari, Italy.
⁴³ Portuguese National Programme for Respiratory Diseases, Direção -Geral da Saúde, Faculdade de Medicina de Lisboa, Instituto de Saúde Ambiental, Lisbon, Portugal.
⁴⁴ University of Central Lancashire Medical School, Preston, UK.
⁴⁵ Department of Geriatrics, Montpellier University Hospital, MUSE, Montpellier, France.
⁴⁶ Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy.
⁴⁷ Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli - IRCCS, Rome, Italy.
⁴⁸ Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
⁴⁹ University Hospital of Nice, Nice, France.
⁵⁰ Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
⁵¹ Department of Medical Sciences, University of Torino, Torino, Italy.
⁵² Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.
⁵³ Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany.
⁵⁴ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain.
⁵⁵ ARADyAL Research Network, Barcelona, Spain.
⁵⁶ Division of Allergy/Immunology, University of South Florida, Tampa, Florida, USA.
⁵⁷ SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
⁵⁸ Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France.
⁵⁹ Universidad Espíritu Santo, Samborondón, Ecuador.
⁶⁰ Respiralab Research Group, Guayas, Ecuador.
⁶¹ ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
⁶² UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto (Porto4Ageing), Porto, Portugal.
⁶³ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
⁶⁴ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
⁶⁵ Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany.
⁶⁶ Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
⁶⁷ Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.
⁶⁸ Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
⁶⁹ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
⁷⁰ Poltava State Medical University, Poltava, Ukraine.
⁷¹ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
⁷² Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Vilnius University, Vilnius, Lithuania.
⁷³ Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania.
⁷⁴ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
⁷⁵ KYomed INNOV, Montpellier, France.
⁷⁶ Faculty of Health Sciences and CICS - UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
⁷⁷ Department of Pulmonary Medicine, CHU Liège, Liège, Belgium.
⁷⁸ GIGA I3 Research Group, University of Liège, Liège, Belgium.
⁷⁹ Allergy Unit "D Kalogeromitros," 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
⁸⁰ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁸¹ Sach's Children and Youth Hospital, Stockholm, Sweden.
⁸² Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
⁸³ Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain.
⁸⁴ Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
⁸⁵ Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
⁸⁶ Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
⁸⁷ Chiba Rosai Hospital, Chiba, Japan.
⁸⁸ Chiba University Hospital, Chiba, Japan.
⁸⁹ Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁹⁰ Berlin Institute of Health, Berlin, Germany.
⁹¹ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁹² Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
⁹³ Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy.
⁹⁴ Agency of Health ASL, Salerno, Italy.
⁹⁵ Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy.
⁹⁶ Department of Public Health, University of Liège, Liège, Belgium.
⁹⁷ Ecole Polytechnique de Palaiseau, Palaiseau, France.
⁹⁸ IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France.
⁹⁹ Université Paris Cité, Paris, France.
¹⁰⁰ Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
¹⁰¹ Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
¹⁰² Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, et UMR 1016, Institut Cochin, Paris, France.
¹⁰³ Department of Otolaryngology, Head and Neck Surgery, Eye and Ear, University Hospital, Beirut, Lebanon.
¹⁰⁴ Department of Otolaryngology, Head and Neck Surgery, Dar Al Shifa Hospital - Salmiya, Hawally, Kuwait.
¹⁰⁵ Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan.
¹⁰⁶ Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain.
¹⁰⁷ PROMISE Department, University of Palermo, Palermo, Italy.
¹⁰⁸ Usher Institute, The University of Edinburgh, Edinburgh, UK.
¹⁰⁹ Department of Respiratory Medicine and Tuberculosis, University Hospital Brno, Lískovec, Czech Republic.
¹¹⁰ Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark.
¹¹¹ Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹¹² Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
¹¹³ UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
¹¹⁴ Imunoalergologia, Faculty of Medicine, Centro Hospitalar Universitário de Coimbra, University of Coimbra, Coimbra, Portugal.
¹¹⁵ Allergy Unit, Málaga Regional University Hospital-IBIMA, Málaga, Spain.
¹¹⁶ International Primary Care Respiratory Group (IPCRG), Aberdeen, UK.
¹¹⁷ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
¹¹⁸ Royal Brompton Hospital, Airways Disease Section, London, UK.
¹¹⁹ Department of Lung Diseases and Clinical Immunology, University of Turku, Turku, Finland.
¹²⁰ FIHLA, Finnish Lung Health Association, Helsinki, Finland.
¹²¹ Department of Clinical Medicine, Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
¹²² Nova Southeastern University, College of Allopathic Medicine, Fort Lauderdale, Florida, USA.
¹²³ Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
¹²⁴ University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.
¹²⁵ Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
¹²⁶ Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
¹²⁷ Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital and Beijing Institute of Otolaryngology, Beijing, China.
¹²⁸ School of Medicine, University CEU San Pablo, Madrid, Spain.
¹²⁹ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
¹³⁰ Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark.

PMID: 37042071
DOI: 10.1111/all.15740

Abstract

Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

Keywords: ARIA; EAACI; apps; digital health; rhinitis.

PubMed Disclaimer

References

REFERENCES

1. Agache I. Severe asthma phenotypes and endotypes. Semin Immunol. 2019;46:101301. doi:10.1016/j.smim.2019.101301
1. Breiteneder H, Peng YQ, Agache I, et al. Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Allergy. 2020;75(12):3039-3068. doi:10.1111/all.14582
1. Porpodis K, Tsiouprou I, Apostolopoulos A, et al. Eosinophilic asthma, phenotypes-Endotypes and current biomarkers of choice. J Pers Med. 2022;12(7):1093. doi:10.3390/jpm12071093
1. Diamant Z, Vijverberg S, Alving K, et al. Toward clinically applicable biomarkers for asthma: an EAACI position paper. Allergy. 2019;74(10):1835-1851. doi:10.1111/all.13806
1. Radzikowska U, Baerenfaller K, Cornejo-Garcia JA, et al. Omics technologies in allergy and asthma research: an EAACI position paper. Allergy. 2022;77(10):2888-2908. doi:10.1111/all.15412

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Consumer Health Information
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

Affiliations

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical