Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;66(9):2063-2070.
doi: 10.1007/s10840-023-01542-8. Epub 2023 Apr 12.

Relationship between coronary blood flow and improvement of cardiac function after catheter ablation for persistent atrial fibrillation

Masao Takahashi  1 , Tomoyuki Arai  2 , Takashi Kimura  2 , Rintaro Hojo  2 , Masayasu Hiraoka  3 , Seiji Fukamizu  2
Affiliations

Relationship between coronary blood flow and improvement of cardiac function after catheter ablation for persistent atrial fibrillation

Masao Takahashi et al. J Interv Card Electrophysiol. 2023 Dec.

Abstract

Background: The relationship between coronary blood flow during atrial fibrillation (AF) and improvement of cardiac function after catheter ablation (CA) for persistent AF (PeAF) is not prominent; this study was conducted to evaluate this relationship.

Methods: This was a retrospective case-control study. Eighty-five patients with PeAF (resting heart rate < 100 bpm) and heart failure with reduced ejection fraction (left ventricular ejection fraction (LVEF) < 40%) who had undergone coronary angiography within 1 week before CA were included. All patients could maintain a sinus rhythm for > 6 months after CA. The primary outcome was improvement of cardiac function with an LVEF cutoff value of > 50% during sinus rhythm 6 months after CA.

Results: In the LVEF improvement group (N = 57), patients were younger, with a higher baseline diastolic blood pressure and lower baseline brain natriuretic peptide level than the no LVEF improvement group (N = 28). Heart rate at baseline and 6 months after CA and AF duration did not differ between the two groups. Thrombolysis in myocardial infarction frame count parameters was significantly higher in the LVEF improvement (P < 0.001) than in the no LVEF improvement group. Multivariate logistic regression analysis revealed mean thrombolysis in myocardial infarction frame count as an independent factor for LVEF improvement (odds ratio, 1.72 (95% confidence interval 1.17-2.54); P = 0.006).

Conclusion: Coronary blood flow in patients with PeAF is strongly associated with improved left ventricular systolic function after the restoration of sinus rhythm by CA for PeAF and heart failure with reduced ejection fraction.

Keywords: Atrial fibrillation; Catheter ablation; Coronary blood flow; Left ventricular systolic function.

PubMed Disclaimer

References

    1. Chugh SS, Blackshear JL, Shen WK, Hammill SC, Gersh BJ. Epidemiology and natural history of atrial fibrillation: clinical implications. J Am Coll Cardiol. 2001;37:371–8. https://doi.org/10.1016/s0735-1097(00)01107-4 . - DOI - PubMed
    1. Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH Jr, Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJ. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129:837–47. https://doi.org/10.1161/CIRCULATIONAHA.113.005119 . - DOI - PubMed
    1. Lévy S, Steinbeck G, Santini L, Nabauer M, Maceda DP, Kantharia BK, Saksena S, Cappato R. Management of atrial fibrillation: two decades of progress - a scientific statement from the European Cardiac Arrhythmia Society. J Interv Card Electrophysiol. 2022;65(1):287–326. https://doi.org/10.1007/s10840-022-01195-z . - DOI - PubMed
    1. Verhaert DVM, Brunner-La Rocca HP, van Veldhuisen DJ, Vernooy K. The bidirectional interaction between atrial fibrillation and heart failure: consequences for the management of both diseases. Europace. 2021;23(Suppl 2):ii40-5. https://doi.org/10.1093/europace/euaa368 . - DOI - PubMed - PMC
    1. Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bänsch D, CASTLE-AF Investigators. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378:417–27. https://doi.org/10.1056/NEJMoa1707855 . - DOI - PubMed

LinkOut - more resources