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. 2023 May 11;388(19):1818-1820.
doi: 10.1056/NEJMc2302462. Epub 2023 Apr 12.

Durability of Bivalent Boosters against Omicron Subvariants

Dan-Yu Lin  1 , Yangjianchen Xu  1 , Yu Gu  1 , Donglin Zeng  1 , Shadia K Sunny  2 , Zack Moore  2
Affiliations

Durability of Bivalent Boosters against Omicron Subvariants

Dan-Yu Lin et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Effectiveness of Bivalent Boosters According to the Interval since Administration.
Shown is the pooled effectiveness of the two bivalent boosters that were evaluated in the study regarding the end points of infection (Panels A and B), severe infection resulting in hospitalization (Panels C and D), severe infection resulting in hospitalization or death (Panels E and F), and severe infection resulting in death (Panels G and H). The left column shows the results of the analysis of all bivalent booster doses, and the right column shows the stratified analysis according to the date of administration. The solid curves show the estimates of booster effectiveness, and the shaded bands indicate 95% confidence intervals. In the right column, each curve starts at the median date of booster administration for participants in that date cohort; the proportions of BA.4, BA.5, BQ.1–BQ.1.1, XBB–XBB.1.5, and other subvariants are indicated below the effectiveness graph.
See this image and copyright information in PMC

References

    1. Lin D-Y, Xu Y, Gu Y, et al. Effectiveness of bivalent boosters against severe omicron infection. N Engl J Med 2023;388:764-766. - PMC - PubMed
    1. Lin D-Y, Gu Y, Wheeler B, et al. Effectiveness of Covid-19 vaccines over a 9-month period in North Carolina. N Engl J Med 2022;386:933-941. - PMC - PubMed
    1. Lin D-Y, Gu Y, Xu Y, et al. Association of primary and booster vaccination and prior infection with SARS-CoV-2 infection and severe COVID-19 outcomes. JAMA 2022;328:1415-1426. - PMC - PubMed