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Comment
. 2023 Apr 11;56(4):742-744.
doi: 10.1016/j.immuni.2023.03.012.

An orphan no more: Nur77 senses cytosolic LPS

Megan H Orzalli  1
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An orphan no more: Nur77 senses cytosolic LPS

Megan H Orzalli. Immunity. .
Free article

Abstract

Cytosolic LPS activates the NLRP3 inflammasome via a gasdermin D (GSDMD)-dependent mechanism. In this issue of Immunity, Zhu et al.1 provide insight into the events linking these two steps, identifying the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation that senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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