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Comment
. 2023 Apr 11;56(4):747-749.
doi: 10.1016/j.immuni.2023.03.013.

Old and "hangry" monocytes turn from friend to foe under assault

Conan J O O'Brien  1 , Ana I Domingos  2
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Free article
Comment

Old and "hangry" monocytes turn from friend to foe under assault

Conan J O O'Brien et al. Immunity. .
Free article

Abstract

Fasting is known to impact monocyte dynamics and phenotype, but the mechanics and functional significance of this response remain unclear. In this issue of Immunity, Janssen and colleagues demonstrate that fasting and re-feeding causes monocytes to re-enter the bone marrow and alter the host response to infection.

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  • Monocytes re-enter the bone marrow during fasting and alter the host response to infection.
    Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK. Janssen H, et al. Immunity. 2023 Apr 11;56(4):783-796.e7. doi: 10.1016/j.immuni.2023.01.024. Epub 2023 Feb 23. Immunity. 2023. PMID: 36827982 Free PMC article.

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