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Review
. 2023 Jun 1:378:110483.
doi: 10.1016/j.cbi.2023.110483. Epub 2023 Apr 10.

Selenium nanoparticles: Properties, preparation methods, and therapeutic applications

Xiang Xiao  1 , Huan Deng  2 , Xue Lin  3 , Ahmed Sameir Mohamed Ali  4 , Angelo Viscardi  5 , Ziwei Guo  6 , Lichun Qiao  7 , Yujie He  8 , Jing Han  9
Affiliations
Review

Selenium nanoparticles: Properties, preparation methods, and therapeutic applications

Xiang Xiao et al. Chem Biol Interact. .

Abstract

Selenium nanoparticles (SeNPs) are a unique type of nano-sized elemental selenium that have recently found wide application in biomedicine. It has been shown that the properties of SeNPs can be varied by different fabrication methods. Moreover, SeNPs have various therapeutic effects in medical applications due to their excellent biological and adaptable physical properties. At the same time, SeNPs can be used as a carrier medium for various therapeutic substances, which can bring out the full curative effects of the drugs. In this review, the differences in bioactivity properties of SeNPs prepared from different substances were reviewed; the therapeutic effects and mechanisms of SeNPs in cancer, inflammation, neurodegenerative diseases, diabetes, reproductive diseases, cardiovascular diseases, and other diseases were discussed; and the importance of the development of SeNPs was further emphasized.

Keywords: Biological properties; Biomedical applications; Mechanism; Preparation methods; Selenium nanoparticles; Toxicity.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jing Han reports financial support was provided by National Natural Science Foundation of China.

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