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. 2023 Apr 12;13(4):e070994.
doi: 10.1136/bmjopen-2022-070994.

Diagnostic accuracy of cryptococcal antigen test in pulmonary cryptococcosis: a protocol for a systematic review and meta-analysis

Binghui Liang  1   2 , Zehui Lin  3 , Jiachun Li  4 , Rongbin Jiang  4 , Weijie Zhan  4 , Xiaoyun Jian  4
Affiliations

Diagnostic accuracy of cryptococcal antigen test in pulmonary cryptococcosis: a protocol for a systematic review and meta-analysis

Binghui Liang et al. BMJ Open. .

Abstract

Background: The cryptococcal antigen (CrAg) test was proposed as a rapid diagnostic tool to identify cryptococcal meningitis in patients suffering from AIDS. Several studies have demonstrated its diagnostic performance in cryptococcal meningitis. However, the diagnostic performance of the CrAg test in serum or bronchoalveolar lavage fluid in patients with pulmonary cryptococcosis remains uncertain. Therefore, the purpose of this systematic review is to summarise the evidence concerning diagnostic performance of the CrAg test in patients with pulmonary cryptococcosis.

Methods and analysis: Databases such as PubMed, EMBASE, Cochrane Database of Systematic Reviews, Web of Science, ClinicalTrials.gov, International Clinical Trials Registry Platform, Wanfang Database and China National Knowledge Infrastructure will be searched systematically. The titles and abstracts will be reviewed by two independent reviewers. The Quality Assessment of Diagnostic Accuracy Studies 2 tool will be used to evaluate the risk of bias and clinical applicability of each study. Potential sources of heterogeneity will be investigated through visual inspection of the paired forest plots and summary receiver operating characteristic plots. The pooled summary statistics for the area under the curve, sensitivities, specificities, likelihood ratios and diagnostic ORs with 95% CI will be reported.

Ethics and dissemination: The underlying study is based on published articles thus does not require ethical approval. The findings of the systematic review and meta-analysis will be published in a peer-reviewed journal and disseminated in various scientific conferences and seminars.

Prospero registration number: CRD42022373321.

Keywords: Clinical Decision-Making; Respiratory infections; Systematic Review.

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Conflict of interest statement

Competing interests: None declared.

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Flow diagram of the study selection process.
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References

    1. Brizendine KD, Baddley JW, Pappas PG. Pulmonary cryptococcosis. Semin Respir Crit Care Med 2011;32:727–34. 10.1055/s-0031-1295720 - DOI - PubMed
    1. Park BJ, Wannemuehler KA, Marston BJ, et al. . Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009;23:525–30. 10.1097/QAD.0b013e328322ffac - DOI - PubMed
    1. Lawrence DS, Muthoga C, Meya DB, et al. . Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-saharan africa: an economic analysis of the AMBITION-cm trial. Lancet Glob Health 2022;10:e1845–54. 10.1016/S2214-109X(22)00450-8 - DOI - PMC - PubMed
    1. Perfect JR, Dismukes WE, Dromer F, et al. . Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases Society of America. Clin Infect Dis 2010;50:291–322. 10.1086/649858 - DOI - PMC - PubMed
    1. Rajasingham R, Govender NP, Jordan A, et al. . The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis. Lancet Infect Dis 2022;22:1748–55. 10.1016/S1473-3099(22)00499-6 - DOI - PMC - PubMed

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