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Meta-Analysis
. 2023 Apr 12;23(1):150.
doi: 10.1186/s12883-023-03176-9.

The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies

Marcos Paulo Braz de Oliveira  1 , Ana Emilia Fonseca de Castro  2 , Andressa Leticia Miri  3 , Carla Rigo Lima  4 , Brendon David Truax  5 , Vanessa Suziane Probst  3 , Suhaila Mahmoud Smaili  3
Affiliations
Meta-Analysis

The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies

Marcos Paulo Braz de Oliveira et al. BMC Neurol. .

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health, sleep and quality of life, especially in individuals with chronic disease. Therefore, the purpose of this systematic review and meta-analysis was to investigate the impact of the COVID-19 pandemic on neuropsychiatric disorders (depression, anxiety, stress), sleep disorders (sleep quality, insomnia) and quality of life in individuals with Parkinson's disease (PD), Multiple Sclerosis (MS) and Alzheimer's disease (AD) compared to healthy controls.

Methods: Seven databases (Medline, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scielo and Lilacs) were searched between March 2020 and December 2022. Observational studies (i.e., cross-sectional, case-control, cohort) were included. GRADE approach was used to assess the quality of evidence and strength of the recommendation. Effect size was calculated using standardized mean differences (SMD; random effects model). A customized Downs and Black checklist was used to assess the risk of bias.

Results: Eighteen studies (PD = 7, MS = 11) were included. A total of 627 individuals with PD (healthy controls = 857) and 3923 individuals with MS (healthy controls = 2432) were analyzed. Twelve studies (PD = 4, MS = 8) were included in the meta-analysis. Individuals with PD had significantly elevated levels of depression (very low evidence, SMD = 0.40, p = 0.04) and stress (very low evidence, SMD = 0.60, p < 0.0001). There was no difference in anxiety (p = 0.08). Individuals with MS had significantly higher levels of depression (very low evidence, SMD = 0.73, p = 0.007) and stress (low evidence, SMD = 0.69, p = 0.03) and low quality of life (very low evidence, SMD = 0.77, p = 0.006). There was no difference in anxiety (p = 0.05) and sleep quality (p = 0.13). It was not possible to synthesize evidence in individuals with AD and sleep disorder (insomnia).

Conclusion: In general, the COVID-19 pandemic negatively impacted individuals with PD and MS. Individuals with PD showed significantly higher levels of depression and stress; and individuals with MS presented significantly higher depression and stress levels, as well as significantly lower quality of life when compared to healthy controls. Further studies are needed to investigate the impact of the COVID-19 pandemic in individuals with AD.

Keywords: Alzheimer disease; COVID-19; Meta-analysis; Multiple sclerosis; Parkinson disease; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of studies selection process. (PD) Parkinson’s disease; (MS) Multiple Sclerosis; (AD) Alzheimer’s disease
Fig. 2
Fig. 2
The forest plots for the grouped studies in individuals with Parkinson's disease for depression, stress, and anxiety
Fig. 3
Fig. 3
The forest plots for the grouped studies in individuals with Multiple Sclerosis for depression, stress, quality of life, anxiety, and sleep quality
See this image and copyright information in PMC

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References

    1. World Health Organization. Statement on the second meeting of the international health regulations (2005) emergency committee regarding the outbreak of novel coronavírus (2019-nCoV). 2020. https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-...). Accessed 15 Mar 2022.
    1. Jin Y, Yang H, Ji W, et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020;12:372. doi: 10.3390/v12040372. - DOI - PMC - PubMed
    1. Geng JS, Yu XL, Bao HN, et al. Chronic diseases as a predictor for severity and mortality of COVID-19: a systematic review with cumulative meta-analysis. Front Med (Lausanne) 2021;8:588013. doi: 10.3389/fmed.2021.588013. - DOI - PMC - PubMed
    1. Pathak N, Vimal SK, Tandon I, Agrawal L, Hongyi C, Bhattacharyya S. Neurodegenerative disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: an early diagnostic approach for precision treatment. Metab Brain Dis. 2022;37:67–104. doi: 10.1007/s11011-021-00800-w. - DOI - PubMed
    1. Erkkinen MG, Kim MO, Geschwind MD. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2018;10:a033118. doi: 10.1101/cshperspect.a033118. - DOI - PMC - PubMed

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