Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 12;14(1):82.
doi: 10.1186/s13287-023-03301-y.

Efficacy of mesenchymal stem cell therapy in rodent models of radiation-induced xerostomia and oral mucositis: a systematic review

Zirui Guan  1 , Jiaxin Zhang  2 , Nan Jiang  2 , Mingyan Tian  1 , Hongyong Wang #  3 , Bing Liang #  4
Affiliations

Efficacy of mesenchymal stem cell therapy in rodent models of radiation-induced xerostomia and oral mucositis: a systematic review

Zirui Guan et al. Stem Cell Res Ther. .

Abstract

Background: Radiation-induced xerostomia and oral mucositis are serious complications of radiation therapy for head and neck cancers. Current treatment options have limited efficacy. Mesenchymal stem cell (MSC) therapy has shown promising results in supporting the restoration of glandular secretion function and the regeneration of damaged tissues. This study aim to (1) assess the quality of evidence for MSCs treatment in rodent models of radiation-induced oral complications and (2) determine whether MSCs can improve the therapeutic effect of radiation-induced oral mucositis.

Methods: Intervention studies using MSCs in rodent models were comprehensively retrieved in the Pubmed, Medline, Embase, Web of Science, and Cochrane library databases on June 1, 2022. The quality of all in vivo experiments was assessed using SYRCLE, and this article is written following the PRISMA guidelines.

Results: A total of 12 studies were included in this systematic review. The study found that in animal models of radiation-induced xerostomia, MSCs could increase salivary protein secretion, improve SFR, shorten the salivary lag time, anti-apoptosis, etc. In animal models of radiation-induced oral mucositis, MSCs improve the micromorphology and macromorphology of RIOM. Moreover, the effect of MSCs on the modification of ulcer duration and latency may be related to the time of MSCs transplantation but further studies are needed.

Conclusion: The results of our systematic review suggest that MSCs appeared to be effective in the treatment of radiation-induced xerostomia and oral mucositis.

Keywords: Ionizing radiation; Mesenchymal stem cells; Oral mucositis; Systematic review; Xerostomia.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Flow diagram of the study selection
Fig. 2
Fig. 2
Overall characteristics of the 12 studies. A Number of publications per year. B Number of papers published per country. C MSC source. E Route of delivery
Fig. 3
Fig. 3
SYRCLE’s RoB tool for each experimental animal study
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Borras JM, Barton M, Grau C, Corral J, Verhoeven R, Lemmens V, et al. The impact of cancer incidence and stage on optimal utilization of radiotherapy: Methodology of a population based analysis by the ESTRO-HERO project. Radiother Oncol. 2015;116(1):45–50. doi: 10.1016/j.radonc.2015.04.021. - DOI - PubMed
    1. van der Veen J, Nuyts S. Can Intensity-modulated-radiotherapy reduce toxicity in head and neck squamous cell carcinoma? Cancers. 2017;9(10):135. doi: 10.3390/cancers9100135. - DOI - PMC - PubMed
    1. Barnett GC, West CML, Dunning AM, Elliott RM, Coles CE, Pharoah PDP, et al. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer. 2009;9(2):134–142. doi: 10.1038/nrc2587. - DOI - PMC - PubMed
    1. Jham BC, da Silva Freire AR. Oral complications of radiotherapy in the head and neck. Braz J Otorhinolaryngol. 2006;72(5):704–708. doi: 10.1016/S1808-8694(15)31029-6. - DOI - PMC - PubMed
    1. Chung EM, Sung EC. Dental management of chemoradiation patients. J Calif Dent Assoc. 2006;34(9):735–742. doi: 10.1080/19424396.2006.12222243. - DOI - PubMed

Publication types

MeSH terms