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Review
. 2023 Mar 31;15(7):2086.
doi: 10.3390/cancers15072086.

Golgi-Targeting Anticancer Natural Products

Myat Nyein Khine  1 , Kaori Sakurai  1
Affiliations
Review

Golgi-Targeting Anticancer Natural Products

Myat Nyein Khine et al. Cancers (Basel). .

Abstract

The Golgi apparatus plays an important role in maintaining cell homeostasis by serving as a biosynthetic center for glycans, lipids and post-translationally modified proteins and as a sorting center for vesicular transport of proteins to specific destinations. Moreover, it provides a signaling hub that facilitates not only membrane trafficking processes but also cellular response pathways to various types of stresses. Altered signaling at the Golgi apparatus has emerged as a key regulator of tumor growth and survival. Among the small molecules that can specifically perturb or modulate Golgi proteins and organization, natural products with anticancer property have been identified as powerful chemical probes in deciphering Golgi-related pathways and, in particular, recently described Golgi stress response pathways. In this review, we highlight a set of Golgi-targeting natural products that enabled the characterization of the Golgi-mediated signaling events leading to cancer cell death and discuss the potential for selectively exploiting these pathways for the development of novel chemotherapeutic agents.

Keywords: Golgi apparatus; anticancer agents; cancer signaling; natural products; stress response.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structural organization of mammalian Golgi apparatus is important for vesicular transport, biosynthesis of glycans and lipids, post-translational modification of proteins and intracellular signaling.
Figure 2
Figure 2
Golgi stress response pathways.
Figure 3
Figure 3
Anticancer natural products that disrupt structural organization of Golgi apparatus.
See this image and copyright information in PMC

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References

    1. Wilson C., Venditti R., Rega L.R., Colanzi A., D’Angelo G., De Matteis M.A. The Golgi apparatus: An organelle with multiple complex functions. Biochem. J. 2011;433:1–9. doi: 10.1042/BJ20101058. - DOI - PubMed
    1. Schjoldager K.T., Narimatsu Y., Joshi H.J., Clausen H. Global view of human protein glycosylation pathways and functions. Nat. Rev. Mol. Cell Biol. 2020;21:729–749. doi: 10.1038/s41580-020-00294-x. - DOI - PubMed
    1. De Graffenried C.L., Bertozzi C.R. The roles of enzyme localization and complex formation in glycan assembly within the Golgi apparatus. Curr. Opin. Cell Biol. 2004;16:356–363. doi: 10.1016/j.ceb.2004.06.007. - DOI - PubMed
    1. Mayinger P. Signaling at the Golgi. Cold Spring Harb. Perspect. Biol. 2011;3:a005314. doi: 10.1101/cshperspect.a005314. - DOI - PMC - PubMed
    1. Chia J., Goh G., Racine V., Ng S., Kumar P., Bard F. RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells. Mol. Syst. Biol. 2012;8:629. doi: 10.1038/msb.2012.59. - DOI - PMC - PubMed

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