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Review
. 2023 Mar 24;24(7):6105.
doi: 10.3390/ijms24076105.

Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases

Tobias Weihrauch  1 , Maren M Limberg  1 , Natalie Gray  1 , Martin Schmelz  2 , Ulrike Raap  1   3
Affiliations
Review

Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases

Tobias Weihrauch et al. Int J Mol Sci. .

Abstract

Allergic diseases are accompanied by a variety of symptoms such as pruritus, coughing, sneezing, and watery eyes, which can result in severe physiological and even psychological impairments. The exact mechanisms of these conditions are not yet completely understood. However, recent studies demonstrated a high relevance of neurotrophins in allergic inflammation, as they induce cytokine release, mediate interaction between immune cells and neurons, and exhibit different expression levels in health and disease. In this review, we aim to give an overview of the current state of knowledge concerning the role of neurotrophins in atopic disorders such as atopic dermatitis, allergic asthma, and allergic rhinitis.

Keywords: allergic asthma; allergic rhinitis; atopic dermatitis; neurotrophin; pruritus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Immune cells release neurotrophins that affect peripheral nerves in the skin.
Figure 2
Figure 2
BDNF released by PAF-stimulated AD eosinophils induces the outgrowth and branching of mouse DRG neurons [7].
See this image and copyright information in PMC

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