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Review
. 2023 Mar 30;24(7):6513.
doi: 10.3390/ijms24076513.

The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

Beatrix Dienes  1 , Tamás Bazsó  2 , László Szabó  1   3 , László Csernoch  1   3
Affiliations
Review

The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

Beatrix Dienes et al. Int J Mol Sci. .

Abstract

Since the recent discovery of the mechanosensitive Piezo1 channels, many studies have addressed the role of the channel in various physiological or even pathological processes of different organs. Although the number of studies on their effects on the musculoskeletal system is constantly increasing, we are still far from a precise understanding. In this review, the knowledge available so far regarding the musculoskeletal system is summarized, reviewing the results achieved in the field of skeletal muscles, bones, joints and cartilage, tendons and ligaments, as well as intervertebral discs.

Keywords: Piezo1; Yoda1; bone; calcium homeostasis; cartilage; joint; ligament; mechanosensitive channels; skeletal muscle; tendon.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of Piezo1 channels in humans: localization of Piezo1 in different organs focusing on musculoskeletal system (the figure was created using biorender.com, accessed on 23 March 2023.).
Figure 2
Figure 2
Piezo1 channel. Structure and regulation of the channel. Piezo1 protein has a homotrimeric architecture with three propeller-shaped blades. The pore consists of the extracellular Cap structure, three pairs of the outer and inner helices (TM domains), and the intracellular C-terminal domain (CTD). The peripheral mechanotransduction region contains the beam structure, the peripheral blade, and the anchor domain (the figure was created using biorender.com).
See this image and copyright information in PMC

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