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Review
. 2023 Apr 1;24(7):6602.
doi: 10.3390/ijms24076602.

S100B, Actor and Biomarker of Mild Traumatic Brain Injury

Charlotte Oris  1   2 , Samy Kahouadji  1   2 , Julie Durif  1 , Damien Bouvier  1   2 , Vincent Sapin  1   2
Affiliations
Review

S100B, Actor and Biomarker of Mild Traumatic Brain Injury

Charlotte Oris et al. Int J Mol Sci. .

Abstract

Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a growing source of morbidity and mortality worldwide. To improve the management of children and adults with mTBI, a series of candidate biomarkers have been investigated in recent years. In this context, the measurement of blood biomarkers in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. In athletes, improved management of sports-related concussions is also sought to ensure athletes' safety. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. In addition to its use as a diagnostic biomarker, S100B plays an active role in the molecular pathogenic processes accompanying acute brain injury. This review describes S100B protein as a diagnostic tool as well as a potential therapeutic target in patients with mTBI.

Keywords: S100B; actor; biomarker; concussion; traumatic brain injury.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scandinavian (A) and French guidelines (B) for the management of patients with mild traumatic brain injury. CT scan: Computed tomography scan; GCS: Glasgow Coma Scale; LOC: Loss of Consciousness.
Figure 2
Figure 2
Hypotheses of S100B protein increase in children, athletes and elderly population.
See this image and copyright information in PMC

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