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Review
. 2023 Mar 23;15(7):1596.
doi: 10.3390/polym15071596.

Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles' Physicochemical Properties on Responses in Biological Systems

Azeez Yusuf  1 , Awatif Rashed Z Almotairy  2 , Hanan Henidi  3 , Ohoud Y Alshehri  4 , Mohammed S Aldughaim  5
Affiliations
Review

Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles' Physicochemical Properties on Responses in Biological Systems

Azeez Yusuf et al. Polymers (Basel). .

Abstract

In the last four decades, nanotechnology has gained momentum with no sign of slowing down. The application of inventions or products from nanotechnology has revolutionised all aspects of everyday life ranging from medical applications to its impact on the food industry. Nanoparticles have made it possible to significantly extend the shelf lives of food product, improve intracellular delivery of hydrophobic drugs and improve the efficacy of specific therapeutics such as anticancer agents. As a consequence, nanotechnology has not only impacted the global standard of living but has also impacted the global economy. In this review, the characteristics of nanoparticles that confers them with suitable and potentially toxic biological effects, as well as their applications in different biological fields and nanoparticle-based drugs and delivery systems in biomedicine including nano-based drugs currently approved by the U.S. Food and Drug Administration (FDA) are discussed. The possible consequence of continuous exposure to nanoparticles due to the increased use of nanotechnology and possible solution is also highlighted.

Keywords: drug delivery systems; nanomedicine; nanoparticles; nanotechnology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Physicochemical properties of nanoparticles.
Figure 3
Figure 3
Targeted delivery and metabolism of liposome encapsulated drug.
Figure 2
Figure 2
Liposomal modification for drug delivery.
Figure 4
Figure 4
Proposed mechanism of action of AgNPs.
See this image and copyright information in PMC

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