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. 2023 Apr 6:16:2632010X231162700.
doi: 10.1177/2632010X231162700. eCollection 2023 Jan-Dec.

Mammary Paget's Disease of Young Females: Case Reports and Comparison With Middle-Aged and Elderly Patients

Chun-Yan Lv  1 , Xian-Kui Cheng  2 , Zhong-Yue Guo  3 , Li Liu  4 , Jian Cai  4 , Tao Lei  1 , Yan Tang  5
Affiliations

Mammary Paget's Disease of Young Females: Case Reports and Comparison With Middle-Aged and Elderly Patients

Chun-Yan Lv et al. Clin Pathol. .

Abstract

Purpose: Mammary Paget's disease (PD) in young women has seldom been reported. The aim of this study was to improve the knowledge of the clinicopathological characteristics in young patients with PD to provide a basis for the precise treatment of young patients.

Methods: The medical records and pathological slides of 8 young patients (younger than 40 years old) with PD were reviewed. The data of 20 patients over 40 years old within the same period were used as controls.

Results: The average age was 32.00 ± 3.96 years for the young patient group, with the youngest aged 27 years. The first symptom, physical examination, Paget cell morphology, and immunohistochemical marks were the same in different age groups. But young patients have varied tumor distribution patterns, fewer interstitial inflammatory cells, and advanced pathological local lymphatic metastasis than older patients in the same period.

Conclusions: PD in young women has unique histopathological features. These manifestations seem to provide personalized treatment for PD treatment in young patients. More research is needed to clarify the significance of this research.

Keywords: Paget’s disease; case reports; comparative study; mammary; young female.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Age histogram for the 96 patients with Paget disease of the Nipple Region (PDNR). Only 2 patients were in their 20s, and 6 patients were in their 30s. The age of peak incidence of PDNR was between the sixth and seventh decades of life, with a median age of 54 years.
Figure 2.
Figure 2.
The morphology of Paget cell: (A) the characteristics of Paget cell (HE staining, 10×) and (B) the cytoplasm around some tumor cells is empty and bright (HE staining, 10×).
Figure 3.
Figure 3.
The proliferation patterns of tumor cell in the epidermis: (A) the tumor cells are mottled (CK7 staining, ×10), (B) acantholysis-like pattern, ALP (HE staining, 10×), (C) glandular pattern, GP (HE staining, 10×), and (D) budding pattern, BP (HE staining, 10×).
Figure 4.
Figure 4.
Hemangioma-like hyperplasia was observed in 1 case.
Figure 5.
Figure 5.
Paget cells involved hair follicles and/or large ducts (CK8/18 immunohistochemical staining, 4×).
Figure 6.
Figure 6.
Immunohistochemical staining: (A) CK8/18, (B) Her-2, (C) CK5/6, and (D) P63.
See this image and copyright information in PMC

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