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. 2023 Mar 27:14:1124565.
doi: 10.3389/fendo.2023.1124565. eCollection 2023.

Association between serum uric acid and phase angle in patients with type 2 diabetes mellitus: A cross-sectional study

Yezi Hu  1 , Jie Liu  2 , Hui Jin  1
Affiliations

Association between serum uric acid and phase angle in patients with type 2 diabetes mellitus: A cross-sectional study

Yezi Hu et al. Front Endocrinol (Lausanne). .

Abstract

Background: The purpose of this analysis was to investigate the associations between serum uric acid and phase angle in patients with type 2 diabetes mellitus.

Methods: In this retrospective cross-sectional study, we included 200 type 2 diabetes mellitus (T2DM) patients treated during 2018-2019 at Zhongda Hospital Southeast University. Phase angle (PhA) and other body composition indicators were measured by bioelectrical impedance analysis (BIA). All patients underwent routine clinical examinations on the day of hospitalization, and the basic information and clinical symptoms of these patients were recorded.

Results: Serum uric acid (UA) was significantly associated with PhA (p <0.001). Overall, in the crude model and minor, all adjusted models (crude model, Models I-II), the phase angle increased as the tertiles of serum uric acid increased. In the minor adjusted model (Model I, adjustment for age and duration) fully adjusted model (Model II, adjustment for age, duration, Lpa, BMI, and WHR), the adjusted β for participants in tertiles of serum uric acid were 0.26 (95% CI: 0.05-0.46) and 0.32 (95% CI: 0.11-0.54), respectively, compared with those in the lowest tertile 1.

Conclusion: There was a nonlinear relationship between serum uric acid and PhA in T2DM patients, and the phase angle increased as uric acid increased within a certain range, and this effect disappeared when uric acid exceeded a certain value.

Keywords: body composition; nutritional status; phase angle; serum uric acid; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of participant selection. T2DM, type 2 diabetes mellitus; BIA, bioelectrical impedance analysis; UA, uric acid.
Figure 2
Figure 2
Association between UA and phase angle. Note: adjust for age + duration + body mass index. UA, uric acid.
Figure 3
Figure 3
Stratification analysis on the association between UA and phase angle. Note: adjust for age + duration + BMI + Lpa + WHR. UA, uric acid; T, tertile; n number; BMI, body mass index.
See this image and copyright information in PMC

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