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Review
. 2023 Mar 27:14:1146991.
doi: 10.3389/fendo.2023.1146991. eCollection 2023.

How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion

Jia Dong  1   2 , Bin Wu  1 , Weidong Tian  2
Affiliations
Review

How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion

Jia Dong et al. Front Endocrinol (Lausanne). .

Abstract

Chronic skin wound healing, especially in diabetes mellitus, is still unsolved. Although many efforts have been made to treat diabetic skin wounds, current strategies have achieved limited effectiveness. Nowadays, a great number of studies have shown that exosomes might be a promising approach for treating diabetic wounds. Many studies and reviews have focused on investigating and discussing the effectiveness and mechanism of exosomes. However, maximizing its value in treating skin wounds in diabetes mellitus requires further consideration. In this review, we reviewed and discussed the aspects that could be further improved in this process, including finding a better source of exosomes, engineering exosomes, adjusting dosage and frequency, and combining more efficient delivery methods. This review provided an overview and idea of what we can do to improve the therapeutic effect of exosomes on skin wounds in diabetes mellitus. Only by combining all the factors that affect the effectiveness of exosomes in diabetic wound healing can we further promote their clinical usefulness.

Keywords: diabetes; exosomes; maximize; skin wounds; therapeutic effect.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Effect of exosomes on modulating different cells in diabetic skin wound healing.
Figure 2
Figure 2
Engineering exosomes for skin wound healing in diabetes mellitus.
Figure 3
Figure 3
Exosome delivery methods for diabetic wounds and the advantages of scaffolds.
Figure 4
Figure 4
The systemic application of exosomes was beneficial to diabetic wounds.
Figure 5
Figure 5
How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus.
See this image and copyright information in PMC

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