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Review
. 2023 Mar 27:13:1165676.
doi: 10.3389/fonc.2023.1165676. eCollection 2023.

MACC1-induced migration in tumors: Current state and perspective

Tim Hohmann  1 , Urszula Hohmann  1 , Faramarz Dehghani  1
Affiliations
Review

MACC1-induced migration in tumors: Current state and perspective

Tim Hohmann et al. Front Oncol. .

Abstract

Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed.

Keywords: MACC1; adhesion; cancer; cytoskeleton; migration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Illustration of migration models. (A) A sketch of the transwell model from the top (top) or side view (bottom). Please note the uneven distribution of pores and unclear cell path (red arrows) before contacting a pore in the top view. The side view shows the necessary, potentially rate-limiting deformation of the nucleus to pass a pore. (B) The working principle of a scratch wound assay, starting from an unscratched monolayer, via wounding, to subsequent wound closure by proliferation and migration. Arrows denote the average direction of migration. (C) Two types of 3D migration models. The top image shows a typical spheroid confrontation assay, bringing the spheroids of two cell populations (gray and pink) into contact, with the subsequent fusion of spheroids and intraspheroidal migration. The bottom image illustrates a typical spheroid invasion assay, showing an embedded spheroid, showing collective and single-cell invasion into the ECM. Arrows illustrate the transition from the start to the end of the experiment.
Figure 2
Figure 2
The MACC1 signaling network associated with cell migration (A) and potential intervention points, with the associated drugs (B).
See this image and copyright information in PMC

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