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Comment
. 2023 May 1;51(5):e129-e130.
doi: 10.1097/CCM.0000000000005796. Epub 2023 Apr 13.

C5a-C5aR1 Axis Blockade in Patients With Severe COVID-19: Contrasting Results of PANAMO and FORCE

Julien Carvelli  1   2   3 , Eric Vivier  2   3   4   5
Affiliations
Comment

C5a-C5aR1 Axis Blockade in Patients With Severe COVID-19: Contrasting Results of PANAMO and FORCE

Julien Carvelli et al. Crit Care Med. .
No abstract available

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References

    1. Carvelli J, Demaria O, Vély F, et al.: Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis. Nature 2020; 588:146–150
    1. Vlaar APJ, Witzenrath M, van Paassen P, et al.: Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): A multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med 2022; 10:1137–1146
    1. Carvelli J, Meziani F, Dellamonica J, et al.; for the FOR COVID Elimination (FORCE) Study Group: Avdoralimab (Anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FOR COVID Elimination [FORCE]) Crit Care Med 2022; 50:1788–1798
    1. Harvey WT, Carabelli AM, Jackson B, et al.: SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev Microbiol 2021; 19:409–424
    1. Rittirsch D, Flierl MA, Nadeau BA, et al.: Functional roles for C5a receptors in sepsis. Nat Med 2008; 14:551–557

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