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Review
. 2023 Aug;60(8):4206-4231.
doi: 10.1007/s12035-023-03328-5. Epub 2023 Apr 13.

Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance

Md Mominur Rahman  1 , Md Rezaul Islam  1 , Fatema Akter Supti  1 , Puja Sutro Dhar  1 , Sheikh Shohag  2 , Jannatul Ferdous  1 , Shakil Khan Shuvo  1 , Aklima Akter  1 , Md Sarowar Hossain  1 , Rohit Sharma  3
Affiliations
Review

Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance

Md Mominur Rahman et al. Mol Neurobiol. 2023 Aug.

Retraction in

Abstract

Neurotrophins and neuropeptides are the essential regulators of peripheral nociceptive nerves that help to induce, sensitize, and maintain pain. Neuropeptide has a neuroprotective impact as it increases trophic support, regulates calcium homeostasis, and reduces excitotoxicity and neuroinflammation. In contrast, neurotrophins target neurons afflicted by ischemia, epilepsy, depression, and eating disorders, among other neuropsychiatric conditions. Neurotrophins are reported to inhibit neuronal death. Strategies maintained for "brain-derived neurotrophic factor (BDNF) therapies" are to upregulate BDNF levels using the delivery of protein and genes or compounds that target BDNF production and boosting BDNF signals by expanding with BDNF mimetics. This review discusses the mechanisms of neurotrophins and neuropeptides against acute neural damage as well as highlighting neuropeptides as a potential therapeutic agent against Parkinson's disease (PD), Huntington's disease (HD), Alzheimer's disease (AD), and Machado-Joseph disease (MJD), the signaling pathways affected by neurotrophins and their receptors in both standard and diseased CNS systems, and future perspectives that can lead to the potent application of neurotrophins and neuropeptides in neurodegenerative diseases (NDs).

Keywords: BDNF; Neurodegenerative disorder; Neuropeptide; Neurotrophin; Therapeutic agent.

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