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Case Reports
. 2023;85(2):44-47.
doi: 10.17116/patol20238502144.

[Gastric cancer with impaired DNA unpaired nucleotide repair system]

[Article in Russian]
D V Rianzhin  1 , G A Raskin  1 , M S Mukhina  1 , I V Rykov  2 , S O Kusin  2 , O V Khodyreva  3
Affiliations
Case Reports

[Gastric cancer with impaired DNA unpaired nucleotide repair system]

[Article in Russian]
D V Rianzhin et al. Arkh Patol. 2023.

Abstract
in English, Russian

This article presents a case of successful treatment of inoperable gastric cancer with impaired mismatched nucleotide repair system (dMMR/MSI-H) in a 72-year-old patient. In view of age, somatic status and the presence of comorbidity, it was decided to prescribe anti-PD-1 therapy in the 1st line of treatment. Currently, after a 2-year course of treatment, the patient is in stable remission.

В данной статье представлен случай успешного лечения неоперабельного рака желудка с нарушением системы репарации неспаренных нуклеотидов (dMMR/MSI-H) у пациентки 72 лет. Ввиду возраста, соматического статуса и наличия сопутствующей патологии было принято решение о назначении анти-PD-1-терапии в 1-й линии лечения. В настоящее время после двухлетнего курса лечения у пациентки наблюдается стойкая ремиссия.

Keywords: anti-PD-1 therapy; gastric cancer; mismatch repair deficiency.

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