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Review
. 2023 Apr 12;31(4):472-484.
doi: 10.1016/j.chom.2023.03.002.

Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions

Rita A Oliveira  1 , Eric G Pamer  2
Affiliations
Free article
Review

Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions

Rita A Oliveira et al. Cell Host Microbe. .
Free article

Abstract

Increasing experimental evidence suggests that administering live commensal bacterial species can optimize microbiome composition and lead to reduced disease severity and enhanced health. Our understanding of the intestinal microbiome and its functions has increased over the past two decades largely due to deep sequence analyses of fecal nucleic acids, metabolomic and proteomic assays to measure nutrient use and metabolite production, and extensive studies on the metabolism and ecological interactions of a wide range of commensal bacterial species inhabiting the intestine. Herein, we review new and important findings that have emerged from this work and provide thoughts and considerations on approaches to re-establish and optimize microbiome functions by assembling and administering commensal bacterial consortia.

Keywords: bacterial consortia; gut microbiome; live biotherapeutic; metabolome.

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Conflict of interest statement

Declaration of interests E.G.P. is an inventor on patent applications No. WPO2015179437A1, entitled “Methods and compositions for reducing Clostridium difficile infection” and No. WPO2017091753A1, entitled “Methods and compositions for reducing vancomycin-resistant Enterococci infection or colonization” and receives royalties from Seres Therapeutics Inc. E.G.P. also serves on the Scientific Advisory Board of Diversigen and on the Gates Foundation Global Health Scientific Advisory Committee.

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