HIV establishes an early foothold

Jose A Moran¹, Matthew D Marsden²

Affiliations

¹ Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA.
² Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Medicine (Division of Infectious Diseases), School of Medicine, University of California Irvine, Irvine, CA, USA. Electronic address: mdmarsde@hs.uci.edu.

PMID: 37054675
DOI: 10.1016/j.chom.2023.03.012

Free article

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HIV establishes an early foothold

Jose A Moran et al. Cell Host Microbe. 2023.

Free article

. 2023 Apr 12;31(4):571-573.

doi: 10.1016/j.chom.2023.03.012.

Authors

Jose A Moran¹, Matthew D Marsden²

Affiliations

¹ Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA.
² Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Medicine (Division of Infectious Diseases), School of Medicine, University of California Irvine, Irvine, CA, USA. Electronic address: mdmarsde@hs.uci.edu.

PMID: 37054675
DOI: 10.1016/j.chom.2023.03.012

Abstract

The weeks following HIV acquisition are a critical time when the virus causes significant immunological damage and establishes long-term latent reservoirs. A recent study in Immunity by Gantner et al. uses single-cell analysis to explore these key early infection events, providing insights into early HIV pathogenesis and reservoir formation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

HIV rapidly targets a diverse pool of CD4⁺ T cells to establish productive and latent infections.
Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N. Gantner P, et al. Immunity. 2023 Mar 14;56(3):653-668.e5. doi: 10.1016/j.immuni.2023.01.030. Epub 2023 Feb 17. Immunity. 2023. PMID: 36804957 Free PMC article.

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HIV establishes an early foothold

Affiliations

HIV establishes an early foothold

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical