Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;11(2):e003164.
doi: 10.1136/bmjdrc-2022-003164.

Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women

Chengjing Huang  1 , Yan Guo  2 , Wei Li  3 , Bing Xiang  1 , Jing Zeng  1 , Feng Zhou  1 , Lu She  1 , Pei Zhang  1 , Shiwei Wang  1 , Bei Liu  4 , Qiong Dai  5 , Mei Yang  6
Affiliations

Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women

Chengjing Huang et al. BMJ Open Diabetes Res Care. 2023 Apr.

Abstract

Introduction: To identify the association of the cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) gene polymorphism with gestational diabetes mellitus (GDM) in the Chinese population.

Research design and methods: This case-control study enrolled 835 pregnant women with GDM and 870 pregnant women without diabetes who underwent antenatal examination during 24 to 28 gestational weeks at the Maternal and Child Health Hospital of Hubei Province from January 15, 2018 to March 31, 2019. Trained nurses collected their clinical information and blood samples. CDKAL1 gene rs10440833, rs10946398, rs4712523, rs4712524, rs7754840, rs7756992 and rs9465871 loci were genotyped by Agena MassARRAY system. SPSS V.26.0 software and online SHesis were used to analyze the relationship between CDKAL1 gene polymorphism and GDM susceptibility.

Results: After being adjusted for maternal age, prepregnancy body mass index (BMI), parity and family history of type 2 diabetes mellitus (T2DM), CDKAL1 gene rs10440833 (AA vs TT, OR=1.631, 95% CI 1.192 to 2.232), rs10946398 (CC vs AA, OR=1.400, 95% CI 1.028 to 1.905), rs4712523 (GG vs AA, OR=1.409, 95% CI 1.038 to 1.913), rs4712524 (GG vs AA, OR=1.418, 95% CI 1.043 to 1.929) and rs7754840 (CC vs GG, OR=1.407, 95% CI 1.036 to 1.911) polymorphisms were all associated with the increased risk of GDM. In addition, there was a powerful linkage disequilibrium (LD) among rs10946398, rs4712523, rs4712524 and rs7754840 (D'>0.900, r2>0.900). And there were significant differences in haplotype CGGC (OR=1.207, 95% CI 1.050 to 1.387) and AAAG (OR=0.829, 95% CI 0.721 o 0.952, p=0.008) between the GDM group and the control group.

Conclusions: rs10440833, rs10946398, rs4712523, rs4712524 and rs7754840 of CDKAL1 gene are associated with GDM susceptibility in central Chinese population.

Keywords: diabetes, gestational; genes.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Selection of subjects for inclusion in the study. GDM, gestational diabetes mellitus.
Figure 2
Figure 2
Inter-single nucleotide polymorphism linkage disequilibrium analysis of CDKAL1 gene (D' test on the left, R2 test on the right).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Queensland Clinical Guidelines . Gestational diabetes mellitus (GDM) [M]. (guideline no.MN21.33-V5-R26). Australia: Queensland Health, 2021: 1–46.
    1. Jun J, Yang HX, Tang X. Gestational diabetes: an opportunity to improve maternal and infant health. Chinese Journal of Perinatal Medicine 2020;23:717–8.
    1. Beucher G, Viaris de Lesegno B, Dreyfus M. Maternal outcome of gestational diabetes mellitus. Diabetes Metab 2010;36:522–37. 10.1016/j.diabet.2010.11.006 - DOI - PubMed
    1. Bellamy L, Casas J-P, Hingorani AD, et al. . Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009;373:1773–9. 10.1016/S0140-6736(09)60731-5 - DOI - PubMed
    1. Johns K, Olynik C, Mase R, et al. . Gestational diabetes mellitus outcome in 394 patients. J Obstet Gynaecol Can 2006;28:122–7. 10.1016/s1701-2163(16)32068-0 - DOI - PubMed

Publication types

Substances