Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Abstract

This study examined whether the relationship between cancer and hand grip strength differs by sex and along the hand grip strength distribution. Using six waves of the Korean Longitudinal Study of Ageing (KLoSA) (N = 9735), sex-stratified unconditional quantile regression models with fixed effects were used to assess sex-specific effects of cancer for patients in different quantiles of the hand grip strength distribution. Cancer diagnosis was negatively associated with hand grip strength for males, but not females, and this sex difference was statistically significant. Quantile regression models showed that the stronger association between cancer and hand grip strength is observed among males with weaker hand grip strength. No statistically significant association was found between hand grip strength and cancer in females across the entire distribution of hand grip strength. This study provided evidence of the heterogeneity in the relationship between cancer and hand grip strength.

Keywords: cancer; fixed effects; hand grip strength; quantile regression; sex differences.