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. 2023 Apr 13;13(1):6058.
doi: 10.1038/s41598-023-33174-3.

Pan-cancer investigation of psoriasis-related BUB1B gene: genetical alteration and oncogenic immunology

Xiaobin Li  1 , Wenwen Wang  2 , Xiaoxia Ding  3
Affiliations

Pan-cancer investigation of psoriasis-related BUB1B gene: genetical alteration and oncogenic immunology

Xiaobin Li et al. Sci Rep. .

Abstract

Unknown factors contribute to psoriasis' hyperproliferative, chronic, inflammatory, and arthritic features. Psoriasis patients have been linked to an increased risk of cancer, though the underlying genetics remain unknown. Since our prior research indicated that BUB1B contributes to the development of psoriasis, we designed and carried out this investigation using bioinformatics analysis. Using the TCGA database, we investigated the oncogenic function of BUB1B in 33 tumor types. To sum up, our work sheds light on BUB1B's function in pan-cancer from various perspectives, including its pertinent signaling pathways, mutation locations, and connection to immune cell infiltration. BUB1B was shown to have a non-negligible role in pan-cancer, which is connected to immunology, cancer stemness, and genetic alterations in a variety of cancer types. BUB1B is highly expressed in a variety of cancers and may serve as a prognostic marker. This study is anticipated to offer molecular details on the elevated cancer risk that psoriasis sufferers experience.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Expression patterns of BUB1B in pan-cancer. (A) For unpaired normal and tumor samples; (B) For paired tumor and normal tissues.
Figure 2
Figure 2
The relationship between BUB1B expression and OS in pan-cancer.
Figure 3
Figure 3
The relationship between the expression of BUB1B and DSS (A), DFI (B), and PF1 (C) in pan-cancer.
Figure 4
Figure 4
Genetic alteration of BUB1B in pan-cancer. (A), (B) The genetic alteration ratios, types, and frequency of BUB1B in pan-cancer. (C) The mutational landscape of BUB1B in pan-cancer. (D)–(G): Genetic alteration differences in UCEC, STAD, LUAD, and ESCA with different expression levels of BUB1B.
Figure 5
Figure 5
The correlation between the SCNAs of BUB1B and immune infiltration in UCEC, LUAD, STAD, and ESCA from the TIMER database.
Figure 6
Figure 6
BUB1B expression and immunological correlation in Pan-cancer. (A) TIMER method; (B) xCell method; (C) association of BUB1B expression and immune checkpoints in pan-cancer.
Figure 7
Figure 7
Association of BUB1B expression and immune microenvironment scores in pan-cancer. (A) Stromal score; (B) Immune score; (C) ESTIMATE score.
Figure 8
Figure 8
Correlation between BUB1B expression and tumor stemness. (A) Association of BUB1B and RNAss in pan-cancer; (B) Association of BUB1B and DNAss in pan-cancer.
Figure 9
Figure 9
Gene sets enrichment analysis of BUB1B. (A) KEGG enrichment analysis of gene set from GEPIA. (B) PPI network of BUB1B-related genes from STRING online tool. (C) KEGG enrichment analysis of gene set from STRING.
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References

    1. Boehncke W-H, Schön MP. Psoriasis. Lancet. 2015;386:983–994. doi: 10.1016/S0140-6736(14)61909-7. - DOI - PubMed
    1. Rademaker M, et al. Psoriasis and cancer. An Australian/New Zealand narrative. Australas J. Dermatol. 2019;60:12–18. doi: 10.1111/ajd.12889. - DOI - PubMed
    1. Loft ND, Vaengebjerg S, Skov L. Cancer risk in patients with psoriasis: Should we be paying more attention? Expert Rev. Clin. Immunol. 2020;16:479–492. doi: 10.1080/1744666X.2020.1754194. - DOI - PubMed
    1. Agapito G, Arbitrio M. Microarray data analysis protocol. Methods Mol. Biol. 2022;2401:263–271. doi: 10.1007/978-1-0716-1839-4_17. - DOI - PubMed
    1. Ferolito B, et al. Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach. Sci. Rep. 2022;12:14914. doi: 10.1038/s41598-022-19244-y. - DOI - PMC - PubMed

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