Overlooked confounding in studies of metabolite salts
- PMID: 37055620
- DOI: 10.1038/s42255-023-00787-x
Overlooked confounding in studies of metabolite salts
Comment on
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The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions.Nat Metab. 2023 Apr;5(4):677-698. doi: 10.1038/s42255-023-00780-4. Epub 2023 Apr 13. Nat Metab. 2023. PMID: 37055619
References
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- Baker, S. A. & Rutter, J. Metabolites as signalling molecules. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-022-00572-w (2023). A review article that presents metabolites as signals that regulate cellular behaviour. - DOI - PubMed
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- Mills, E. L. et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 560, 102–106 (2018). This paper reports that the Krebs cycle intermediate, succinate, can accumulate in brown adipose tissue and drive non-shivering thermogenesis to counteract weight gain. - DOI - PubMed - PMC
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