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Review
. 2023 Mar 28:14:1153585.
doi: 10.3389/fgene.2023.1153585. eCollection 2023.

Comprehensive analysis of epigenetics mechanisms in osteoporosis

Yuzhu Chen  1 , Yumiao Sun  1 , Xiangyu Xue  2 , Huanzhi Ma  3
Affiliations
Review

Comprehensive analysis of epigenetics mechanisms in osteoporosis

Yuzhu Chen et al. Front Genet. .

Abstract

Epigenetic modification pertains to the alteration of genetic-expression, which could be transferred to the next generations, without any alteration in the fundamental DNA sequence. Epigenetic modification could include various processes such as DNA methylation, histone alteration, non-coding RNAs (ncRNAs), and chromatin adjustment are among its primary operations. Osteoporosis is a metabolic disorder that bones become more fragile due to the decrease in mineral density, which could result in a higher risk of fracturing. Recently, as the investigation of the causal pathology of osteoporosis has been progressed, remarkable improvement has been made in epigenetic research. Recent literatures have illustrated that epigenetics is estimated to be one of the most contributing factors to the emergence and progression of osteoporosis. This dissertation primarily focuses on indicating the research progresses of epigenetic mechanisms and also the regulation of bone metabolism and the pathogenesis of osteoporosis in light of the significance of epigenetic mechanisms. In addition, it aims to provide new intelligence for the treatment of diseases related to bone metabolism.

Keywords: DNA methylation; epigenetics; histone modification; non-coding RNA (ncRNAs); osteoporosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The specific process of Wnt/β-catenin signaling pathway in bone metabolism.
FIGURE 2
FIGURE 2
miRNA, lncRNA and circRNA affect bone metabolism and participate in the occurrence and development of osteoporosis.
See this image and copyright information in PMC

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