Fluorescence confocal microscopy on liver specimens: Could it be a game changer in transplantation pathology?

Albino Eccher¹, Dorry Segev^{2

3}, Ugo Boggi⁴

Affiliations

¹ Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
² Department of Surgery, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
³ Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
⁴ Department of Surgery, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Editorial

Albino Eccher et al. Liver Transpl. 2023.

. 2023 Sep 1;29(9):915-916.

doi: 10.1097/LVT.0000000000000159. Epub 2023 Apr 17.

Albino Eccher¹, Dorry Segev^{2

3}, Ugo Boggi⁴

¹ Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
² Department of Surgery, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
³ Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
⁴ Department of Surgery, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

No abstract available

Comment on

Ex Vivo Fluorescence Confocal Microscopy in Specimens of the Liver: A Proof-of-Concept Study.
Titze U, Sievert KD, Titze B, Schulz B, Schlieker H, Madarasz Z, Weise C, Hansen T. Titze U, et al. Cancers (Basel). 2022 Jan 25;14(3):590. doi: 10.3390/cancers14030590. Cancers (Basel). 2022. PMID: 35158859 Free PMC article.
Fluorescence confocal microscopy on liver specimens for full digitization of transplant pathology.
Kinzler MN, Schulze F, Reitz A, Gretser S, Ziegler P, Shmorhun O, Friedrich-Rust M, Bojunga J, Zeuzem S, Schnitzbauer AA, Bechstein WO, Reis H, Barreiros AP, Wild PJ. Kinzler MN, et al. Liver Transpl. 2023 Sep 1;29(9):940-951. doi: 10.1097/LVT.0000000000000142. Epub 2023 Apr 6. Liver Transpl. 2023. PMID: 37016761

1. Krishnamurthy S, Sabir S, Ban K, Wu Y, Sheth R, Tam A, et al. Comparison of real-time fluorescence confocal digital microscopy with hematoxylin-eosin-stained sections of core-needle biopsy specimens. JAMA Netw Open. 2020;3:e200476.
1. Rocco B, Sighinolfi MC, Sandri M, Spandri V, Cimadamore A, Volavsek M, et al. Digital biopsy with fluorescence confocal microscope for effective real-time diagnosis of prostate cancer: A prospective, comparative study. Eur Urol Oncol. 2021;4:784–91.
1. Titze U, Sievert KD, Titze B, Schulz B, Schlieker H, Madarasz Z, et al. Ex vivo fluorescence confocal microscopy in specimens of the liver: A proof-of-concept study. Cancers (Basel). 2022;14:590.
1. Marletta S, Pantanowitz L, Malvi D, Novelli L, Mescoli C, Cardillo M, et al. Validation of portable tablets for transplant pathology diagnosis according to the College of American Pathologists Guidelines. Acad Pathol. 2022;9:100047.
1. Eccher A, Girolami I, Brunelli M, Novelli L, Mescoli C, Malvi D, et al. Digital pathology for second opinion consultation and donor assessment during organ procurement: Review of the literature and guidance for deployment in transplant practice. Transplant Rev (Orlando). 2020;34:100562.