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Review
. 2023 Aug;149(10):8153-8164.
doi: 10.1007/s00432-023-04743-w. Epub 2023 Apr 14.

The role of Pcdh10 in neurological disease and cancer

Yilan Zhen  1 , Macarena Pavez #  2 , Xinying Li #  3   4
Affiliations
Review

The role of Pcdh10 in neurological disease and cancer

Yilan Zhen et al. J Cancer Res Clin Oncol. 2023 Aug.

Abstract

Background: Protocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2+-dependent homophilic cell-cell adhesion molecule expressed on the surface of cell membranes. Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neural circuits and synapses, regulation of actin assembly, cognitive function and tumor suppression. Additionally, Pcdh10 can serve as a non-invasive diagnostic and prognostic indicator for various cancers.

Methods: This paper collects and reviews relevant literature in Pubmed.

Conclusion: This review describes the latest research understanding the role of Pcdh10 in neurological disease and human cancer, highlighting the importance of scrutinizing its properties for the development of targeted therapies and identifying a need for further research to explore Pcdh10 functions in other pathways, cell types and human pathologies.

Keywords: Cancer; Epigenetic therapy; Methylation; Neurological disease; Protocadherin10; Tumor; Tumor suppressor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Mechanisms of Pcdh10 activity required to drive and maintain physiological and brain developmental functions. A Pcdh10 can bind Nap1, CYFIP2, Abi-1, HSPC300 and WAVE1 to form a Pcdh10-WAVE regulatory complex. By recruiting the WAVE regulatory complex to inter-axonal contact sites, Pcdh10 regulates F-actin organization and N-cadherin redistribution. Redistributed N-cadherin is unable to induce contact inhibition, leading to increased cell migration of glioblastoma cells. B Nuclear MEF2 activation initiates Mdm2 transcription, which results in ubiquitination of PSD-95. Pcdh10 then binds to ubiquitinated PSD-95 and links it to the proteasome for degradation, resulting in synapse elimination
Fig. 2
Fig. 2
Genes involved in the Pcdh10 regulatory network in human cancer. Genes listed in white background are upstream regulators of Pcdh10, genes listed in light yellow background are downstream regulators of Pcdh10
See this image and copyright information in PMC

References

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