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. 2024:284:133-150.
doi: 10.1007/164_2023_651.

Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges

Marieta Duvnjak #  1 , Alessia Villois  1 , Farshad Ramazani #  2
Affiliations

Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges

Marieta Duvnjak et al. Handb Exp Pharmacol. 2024.

Abstract

Long-acting injectables have been used to benefit patients with chronic diseases. So far, several biodegradable long-acting platform technologies including drug-loaded polymeric microparticles, implants (preformed and in situ forming), oil-based solutions, and aqueous suspension have been established. In this chapter, we summarize all the marketed technology platforms and discuss their challenges regarding development including but not limited to controlling drug release, particle size, stability, sterilization, scale-up manufacturing, etc. Finally, we discuss important criteria to consider for the successful development of long-acting injectables.

Keywords: Controlled release; Extended release; Long-acting injectables; Microcrystal suspensions; Microspheres; Oil solution; PLGA microparticles; Preformed and in situ forming implants; Sustained release.

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