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. 2023 Apr 14;21(1):35.
doi: 10.1186/s12969-023-00814-x.

The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register

M Backström  1   2   3 , H Salo  4 , J Kärki  5   6 , K Aalto  7 , K Rebane  7 , T Levälampi  7 , M-M Grönlund  8 , L Kröger  9 , H Pohjankoski  10 , M Hietanen  10 , K Korkatti  11 , L Kuusalo  12 , V Rantalaiho  13   14   15 , J Huhtakangas  16 , H Relas  17 , T Pääkkö  18 , E Löyttyniemi  19 , T Sokka-Isler  20 , P Vähäsalo  21   22   23
Affiliations

The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register

M Backström et al. Pediatr Rheumatol Online J. .

Abstract

Background: The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes erythrocyte sedimentation rate (ESR). Three different sets of JADAS10/cJADAS10 cut-offs for disease activity states have been published, i.e., the Backström, Consolaro, and Trincianti cut-offs. The objective of this study was to investigate the performance of existing JADAS10 cut-offs in real-life settings using patient data from The Finnish Rheumatology Quality Register (FinRheuma).

Methods: Data were collected from the FinRheuma register. The proportion of patients with an active joint count (AJC) above zero when classified as being in clinically inactive disease (CID) or low disease activity (LDA) groups according to existing JADAS10/cJADAS10 cut-off levels were analyzed.

Results: A significantly larger proportion of the patients classified as being in CID had an AJC > 0 when using the JADAS10/cJADAS10 cut-offs by Trincianti et al. compared to those for the other cut-offs. In the LDA group, a significantly larger proportion of the polyarticular patients (35%/29%) had an AJC of two when Trincianti JADAS10/cJADAS10 cut-offs were used compared with when Backström (11%/10%) and Consolaro (7%/3%) JADAS10/cJADAS10 cut-offs were used.

Conclusions: We found the cut-offs proposed by Consolaro et al. to be the most feasible, since these cut-off levels for CID do not result in the misclassification of active disease as remission, and the proportion of patients with AJC > 1 in the LDA group is lowest using these cut-offs.

Keywords: Disease activity; Juvenile idiopathic arthritis; Outcome measures.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Distribution of the disease activity levels in treatment-naïve oligoartricular (A, C) and polyartricular (B, D) patients based on JADAS cut-off values (A, B) and cJADAS cut-off values (C, D) according to Backström et al. [13, 17], Consolaro et al. [12, 16, 19] and Trincianti et al. [20]
Fig. 2
Fig. 2
Distribution of the disease activity levels in oligoartricular (A, C) and polyartricular (B, D) patients during the latest visit in The Finnish Rheumatology Quality Register based on JADAS cut-off values (A, B) and cJADAS cut-off values (C, D) according to Backström et al. [13, 17], Consolaro et al. [12, 16, 19] and Trincianti et al. [20]
See this image and copyright information in PMC

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