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Review
. 2023 Apr 14;20(1):68.
doi: 10.1186/s12985-023-02033-y.

Genetic variants of Dabie bandavirus: classification and biological/clinical implications

Bingyan Liu #  1 , Jie Zhu #  1 , Tengfei He  1 , Zhenhua Zhang  2
Affiliations
Review

Genetic variants of Dabie bandavirus: classification and biological/clinical implications

Bingyan Liu et al. Virol J. .

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV), a novel Bandavirus in the family Phenuiviridae. The first case of SFTS was reported in China, followed by cases in Japan, South Korea, Taiwan and Vietnam. With clinical manifestations including fever, leukopenia, thrombocytopenia, and gastrointestinal symptoms, SFTS has a fatality rate of approximately 10%. In recent years, an increasing number of viral strains have been isolated and sequenced, and several research groups have attempted to classify the different genotypes of DBV. Additionally, accumulating evidence indicates certain correlations between the genetic makeup and biological/clinical manifestations of the virus. Here, we attempted to evaluate the genetic classification of different groups, align the genotypic nomenclature in different studies, summarize the distribution of different genotypes, and review the biological and clinical implications of DBV genetic variations.

Keywords: Dabie bandavirus (DBV); Distribution of DBV; Evolutionary rate; Genetic variation; Genotype; Severe fever with thrombocytopenia syndrome (SFTS).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
A DBV structure. Viral structure with its protein components and viral RNA, and the amino acid variation sites which alter the biological properties of DBV. B Diagram of the genomic structure of DBV and the evolutionary rate of each segment [–46]
Fig. 2
Fig. 2
Distribution of DBV genotypes in different countries by different genotyping methods. The dataset used are from Yun et al. [10]. Cases were reported from China, Japan and Korea. Graphs are shown in the order of genotyping methods A–F, A–E and C–J
Fig. 3
Fig. 3
Distribution of DBV genotypes in different regions of China. Data for Fig. 3 is cited from Li et al. [55]. The genotyping method is A–E. The abscissa denotes provinces in China. AH Anhui province; JS Jiangsu province; HN Henan province; SD Shandong province; HB Hubei province; ZJ Zhejiang province; LN Liaoning province
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