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. 2023 Sep;33(9):6448-6458.
doi: 10.1007/s00330-023-09625-w. Epub 2023 Apr 15.

Defining subventricular zone involvement to predict the survival of patients in isocitrate dehydrogenase-wild type glioblastoma: validation in a prospective registry

Ji Eun Kim  1 , Ji Eun Park  2 , Seo Young Park  3 , Young-Hoon Kim  4 , Chang-Ki Hong  4 , Jeong Hoon Kim  4 , Ho Sung Kim  1
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Defining subventricular zone involvement to predict the survival of patients in isocitrate dehydrogenase-wild type glioblastoma: validation in a prospective registry

Ji Eun Kim et al. Eur Radiol. 2023 Sep.

Abstract

Objectives: The prognostic value of subventricular zone distance (SVD) is unclear because of different definitions and lack of evaluation of clinical survival models. The aim of this study was to define SVD and evaluate its prognostic value in a survival nomogram for glioblastoma.

Methods: This retrospective study included 158 (SVD biomarker) from historical glioblastoma patients and 187 (survival modeling) with IDH-wild type glioblastoma from a prospective registry (NCT02619890). SVD was assessed by two radiologists: definition 1, the distance between the tumor edge to subventricular zone (SVZ); definition 2, the distance between the tumor centroid to SVZ; definition 3, enhancement at the ventricular wall. The associations between SVD and overall survival (OS) were evaluated using multivariable Cox proportional hazards regression analysis. Performance of an updated SVD survival model was compared with that of the Radiation Therapy Oncology Group (RTOG) 0525 nomogram.

Results: SVD according to both definition 1 (hazard ratio [HR]: 0.97, 95% CI: 0.94-0.99; p = .011) and definition 2 (HR: 0.96, 0.94-0.98, p < .001) was adversely associated with OS. Definition 1 was adversely associated with PFS (HR: 0.96, 0.94-0.99, p = .008) and showed the highest reproducibility (intraclass correlation coefficient, 0.90). The SVD-updated model showed similar to better performance than the RTOG model for predicting OS of up to 3 years (AUC: 0.735-0.738 vs. 0.687-0.708), with higher time-dependent specificity for 1-year (89.9% vs. 70.6%) and 3-year OS (93.3% vs. 80.0%).

Conclusion: SVZ distance is an independent adverse prognostic factor in patients with IDH-wild type glioblastoma. Updating the survival model with SVZ provides better time-dependent specificity and reproducibility.

Key points: • Subventricular zone distance (SVD) measurement from tumor edge showed high reproducibility. • Longer SVD was independently associated with longer overall survival. • Adding SVD improved time-dependent specificity for survival model in a prospective registry.

Keywords: Glioblastoma; MRI; Radiation Oncology; Subventricular zone; Survival.

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References

    1. Stupp R, Hegi ME, Mason WP et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459–466 - DOI - PubMed
    1. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492–507 - DOI - PubMed
    1. Network NCC (2022) NCCN guidelines; central nervous system cancers. National Comprehensive Cancer Network 2022 (Accessed October 10, 2022, at https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf ) version 2022.02
    1. Saito T, Muragaki Y, Maruyama T et al (2020) Influence of wide opening of the lateral ventricle on survival for supratentorial glioblastoma patients with radiotherapy and concomitant temozolomide-based chemotherapy. Neurosurg Rev 43:1583–1593 - DOI - PubMed
    1. Mistry AM, Hale AT, Chambless LB, Weaver KD, Thompson RC, Ihrie RA (2017) Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis. J Neurooncol 131:125–133 - DOI - PubMed

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