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Review
. 2023 Jun:112:102741.
doi: 10.1016/j.ceca.2023.102741. Epub 2023 Apr 7.

Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

Ellen K Janke  1 , Silke B Chalmers  2 , Sarah J Roberts-Thomson  1 , Gregory R Monteith  3
Affiliations
Review

Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

Ellen K Janke et al. Cell Calcium. 2023 Jun.

Abstract

Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca2+) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca2+ signalling and EMT will be explored. An overview of the Ca2+ pathways that are remodelled as a consequence of EMT is provided and the role of Ca2+ signalling in regulating EMT and its significance is considered. Ca2+ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca2+ signalling is to be manipulated with the aim of therapeutic intervention in cancer.

Keywords: Calcium signalling; Cancer; EMT; Epithelial; Mesenchymal.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Greg Monteith reports financial support was provided by National Health and Medical Research Council of Australia and the Office of the Assistant Secretary of defence for Health Affairs, through the Breast Cancer Research Program.

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